Conversion from bipolar disorder not otherwise specified (BP-NOS) to bipolar I or II in youth with family history as a predictor of conversion.
Conversion from bipolar disorder not otherwise specified (BP-NOS) to bipolar I or II in youth with family history as a predictor of conversion.
复制标题
在有家族史的青少年中，从未另行指定的双相情感障碍 (BP-NOS) 转变为双相 I 型或 II 型，可作为转变的预测因素。
DOI：
10.1016/j.jad.2012.06.018
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发表时间：
2013
影响因子：
6.6
通讯作者：
Fristad,MaryA
中科院分区：
文献类型：
--
作者：
Martinez,MollyS;Fristad,MaryA
BACKGROUNDBipolar disorder-not otherwise specified (BD-NOS) is an imprecise, heterogeneous diagnosis that is unstable in youth. This study reports rates of conversion from BD-NOS to BD-I or II in children aged 8–12, and investigates the impact of family history of bipolar disorder and depression on conversion.METHODSAs part of the Multi-Family Psychoeducational Psychotherapy (MF-PEP) study, 27 children (6–12 years of age) diagnosed with BD-NOS at baseline were reassessed every 6 months over an 18-month period. Family history of bipolar disorder and depression was assessed at baseline.RESULTSOne-third of the sample converted from BD-NOS to BD-I or II over 18-months. Having a first-degree relative with symptoms of bipolar disorder and having a loaded pedigree for diagnosis of depression each were associated with conversion from BD-NOS to BD-I or II (odds ratio range: 1.09–3.14; relative risk range: 1.06–2.34).LIMITATIONSThis study had very low power (range: 10–45) given the small sample size, precluding statistical significance of non-parametric Fisher's Exact test findings.CONCLUSIONSThis study replicates the previous finding of a high rate of conversion from BD-NOS to BD-I or II among youth, and suggests conversion is related to symptoms of bipolar disorder or depression diagnoses in the family history. Additional research is warranted in a larger sample with a longer follow-up period.
