Mechanisms of lymphocyte migration in autoimmune disease.
Mechanisms of lymphocyte migration in autoimmune disease.
复制标题
自身免疫性疾病中淋巴细胞迁移的机制。
DOI：
10.1111/j.1399-0039.2005.00434.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Hickey,MJ
中科院分区：
文献类型：
--
作者：
Norman,MU;Hickey,MJ
白细胞向发炎组织的募集在对抗感染和促进伤口愈合中起重要作用。然而，在自身免疫性疾病如多发性硬化症和糖尿病中，白细胞进入组织并导致不适当的炎症反应，这导致组织损伤和功能障碍。在这种类型的疾病中，淋巴细胞在启动和维持这些异常炎症反应中起关键作用。本综述的目的是研究T淋巴细胞进入自身免疫性疾病组织的机制，并比较各种器官和疾病之间的这些机制。概述了白细胞募集的机制和用于研究白细胞运输的技术，重点是使用活体显微镜作为评估体内功能性微血管的工具。我们还讨论了一系列的组织归巢事件，使幼稚淋巴细胞首先进入淋巴结，并进行激活，然后回家的周边器官，其同源抗原存在。最后，我们研究了白细胞在多发性硬化症、自身免疫性糖尿病、系统性红斑狼疮、类风湿性关节炎、炎症性肠病和哮喘等疾病中的募集机制。
The recruitment of leukocytes to inflamed tissues plays an essential role in combating infection and promoting wound healing. However, in autoimmune diseases such as multiple sclerosis and diabetes, leukocytes enter tissues and contribute to inappropriate inflammatory responses, which cause tissue injury and dysfunction. In diseases of this type, lymphocytes play critical roles in initiating and maintaining these aberrant inflammatory responses. The aim of this review is to examine the mechanisms whereby T‐lymphocytes enter tissues in autoimmune diseases and to compare these mechanisms between various organs and diseases. An overview of the mechanisms of leukocyte recruitment and the techniques used to study leukocyte trafficking is provided, focusing on the use of intravital microscopy as a tool to assess the functional microvasculaturein vivo. We also discuss the series of tissue homing events which allow naïve lymphocytes to first enter lymph nodes and undergo activation, then subsequently to home to the peripheral organ where their cognate antigen is present. Finally, we examine mechanisms of leukocyte recruitment in diseases such as multiple sclerosis, autoimmune diabetes, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease and asthma.