Panel-reactive antibody levels and renal transplantation rates in sensitized patients after desensitization and human leucocyte antigen amino acid residue matching
Panel-reactive antibody levels and renal transplantation rates in sensitized patients after desensitization and human leucocyte antigen amino acid residue matching
复制标题
脱敏和人白细胞抗原氨基酸残基匹配后致敏患者的面板反应抗体水平和肾移植率
DOI：
10.1177/0300060513485896
复制
发表时间：
2013-08-01
影响因子：
1.6
通讯作者：
Zhang, Weihong
中科院分区：
文献类型：
--
作者：
Shang, Wenjun;Dong, Laidong;Zhang, Weihong
目的探讨一种新的脱敏方案(霉酚酸酯[MMF]、血浆置换和抗胸腺细胞球蛋白[ATG]，辅以人类白细胞抗原[HLA]氨基酸残基匹配)能否降低致敏患者的群体反应性抗体(PRA)水平，以促进肾移植的成功。PRA水平为
Objective To determine whether a new desensitization protocol (mycophenolate mofetil [MMF], plasmapheresis and antithymocyte globulin [ATG], complemented with human leucocyte antigen [HLA] amino acid residue matching) could reduce panel-reactive antibody (PRA) levels in sensitized patients, to facilitate successful renal transplantation.Methods Patients awaiting transplantation with PRA levels >10% received treatment with MMF; those with PRA levels >30% were also treated with plasmapheresis. Patients whose PRA level was