Carotid geometry effects on blood flow and on risk for vascular disease
Carotid geometry effects on blood flow and on risk for vascular disease
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DOI：
10.1016/j.jbiomech.2007.08.012
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Papavassiliou, Dimitrios V.
中科院分区：
文献类型：
--
作者：
Nguyen, Kien T.;Clark, Christopher D.;Papavassiliou, Dimitrios V.
人们广泛观察到，动脉粥样硬化性疾病发生在血流动力学复杂的部位，如动脉分叉、连接处和高曲率区域。这些区域通常具有非常低或高振荡壁剪切应力（WSS）。在目前的工作中，使用有限体积数值方法模拟了通过颈动脉分叉模型的三维脉动血流量。目的是量化与不同颈动脉几何形状相关的动脉粥样硬化风险。提出了一个基于颈内动脉窦壁平均WSS的风险量表，该量表可用于量化颈动脉几何形状对发生血管疾病的相对风险的影响。研究发现，颈内动脉的分岔角和面外角对颈动脉壁上低应力区形成有影响。主要结论是：(a)较大的颈内动脉角（θ (IC)）通常会增加血液再循环的频率和面积，降低窦壁上的WSS，从而增加斑块形成的风险；(b)对于θ (IC) >= 25度的几何形状，发现离平面角度降低了鼻窦上的WSS。较大的离平面角度通常会增加鼠疫积聚的危险；(c)为（IC）
It has been widely observed that atherosclerotic diseases occur at sites with complex hemodynamics, such as artery bifurcations, junctions, and regions of high curvature. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present work, 3D pulsatile blood flow through a model of the carotid artery bifurcation was simulated using a finite volume numerical method. The goal was to quantify the risk of atherogenesis associated with different carotid artery geometries. A risk scale based on the average WSS on the sinus wall of the internal carotid artery was proposed-a scale that can be used to quantify the effect of the carotid geometry on the relative risk for developing vascular disease. It was found that the bifurcation angle and the out-of-plane angle of the internal carotid artery affect the formation of low stress regions on the carotid walls. The main conclusions are: (a) larger internal carotid artery angles (theta(IC)) generally increase the frequency and the area of blood recirculation and lower the WSS on the sinus wall, hence increasing the risk of plaque build-up; (b) off-plane angles were found to lower the WSS on the sinus for geometries with theta(IC) >= 25 degrees. Larger off-plane angles generally increase the danger of plague build-up; (c) for theta(IC)