Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.
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DOI：
10.1155/mi.2005.273
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发表时间：
2005-10-24
影响因子：
4.6
通讯作者：
Ciragil P
中科院分区：
文献类型：
--
作者：
Arican O;Aral M;Sasmaz S;Ciragil P
对银屑病认识的最新进展表明，局部和全身细胞因子的调节在其发病机制中发挥着重要作用。最常用的银屑病评分是银屑病面积和严重程度指数（PASI）。对血液样本进行简单的实验室测试将是一种有吸引力的、独立于患者和观察者的疾病严重程度标记。为此，我们评估了体内一些促炎细胞因子的血清水平及其与银屑病严重程度的相关性。使用ELISA方法测定血清细胞因子水平。除IL-17水平外，患者的所有平均值均显着高于对照组。血清IFN-γ、IL-12、IL-17和IL-18水平与疾病严重程度之间存在显着相关性。牛皮癣可以被描述为一种 T 细胞介导的疾病，多种细胞因子具有复杂的作用，这导致了新的免疫调节疗法的发展。在这项研究中，活动性银屑病患者的血清 TNF-α、IFN-γ、IL-6、IL-8、IL-12 和 IL-18 水平显着高于对照组。此外，高水平的 IFN-γ、IL-12 和 IL-18 与银屑病的临床严重程度和活动性相关，这些细胞因子血清水平的测量可能是疾病严重程度的客观参数。
Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-γ, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IFN-γ, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity.