Relationship between leukocyte telomere length and personality traits in healthy subjects
Relationship between leukocyte telomere length and personality traits in healthy subjects
复制标题
健康受试者白细胞端粒长度与人格特征的关系
DOI：
10.1016/j.eurpsy.2014.03.003
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Otani K
中科院分区：
文献类型：
--
作者：
Sadahiro R;Suzuki A;Enokido M;Matsumoto Y;Shibuya N;Kamata M;Goto K;Otani K
研究背景研究表明，某些人格特征与死亡率和疾病发病率有关，但它们之间的生物学机制尚不清楚。端粒是位于染色体末端的串联重复DNA序列，较短的端粒长度是死亡率和晚年疾病发病率的预测因子。因此，人格特质可能会影响端粒长度。在本研究中，我们探讨了白细胞端粒长度与人格特质的关系在healthy subjects.Subjects和methodsThe科目是209无关的健康日本人谁被招募的医学生在第4 - 5级。人格特质的评估采用修订的NEO人格量表（NEO-PI-R）和气质和性格量表（TCI）。结果在逐步多元回归分析中，端粒长度越短，神经质得分越低（P < 0.01）和责任心NEO-PI-R组与对照组比较差异有统计学意义（P < 0.05），伤害回避得分也较低（P < 0.05）和奖励依赖结论白细胞端粒长度与某些人格特征有关，这种关联可能与人格特质和死亡率之间的关系有关。
BackgroundIt has been shown that certain personality traits are related to mortality and disease morbidity, but the biological mechanism linking them remains unclear. Telomeres are tandem repeat DNA sequences located at the ends of chromosomes, and shorter telomere length is a predictor of mortality and late-life disease morbidity. Thus, it is possible that personality traits influence telomere length. In the present study, we examined the relationship of leukocyte telomere length with personality traits in healthy subjects.Subjects and methodsThe subjects were 209 unrelated healthy Japanese who were recruited from medical students at 4th–5th grade. Assessment of personality traits was performed by the Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI). Leukocyte relative telomere length was determined by a quantitative real-time PCR method for a ratio of telomere/single copy gene.ResultsIn the stepwise multiple regression analysis, shorter telomere length was related to lower scores of neuroticism (P < 0.01) and conscientiousness (P < 0.05) of the NEO-PI-R, and lower scores of harm avoidance (P < 0.05) and reward dependence (P < 0.05) of the TCI.ConclusionsThe present study suggests that leukocyte telomere length is associated with some personality traits, and this association may be implicated in the relationship between personality traits and mortality.