Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males.
Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males.
复制标题
DOI：
10.1152/japplphysiol.00220.2017
复制
发表时间：
2017-05
影响因子：
3.3
通讯作者：
T. Amano;Yosuke Shitara;Naoto Fujii;Y. Inoue;N. Kondo
中科院分区：
文献类型：
--
作者：
T. Amano;Yosuke Shitara;Naoto Fujii;Y. Inoue;N. Kondo
本研究的目的是确定β-肾上腺素能对习惯性训练的男性在增量运动中出汗的贡献。9名习惯性训练的男性和11名未训练的男性进行增量循环，直到精疲力竭（20 W/min）。在两个皮肤部位测量双侧前臂出汗率（通气胶囊），通过离子透皮给药，分别给予1%心得安（心得安，一种非选择性β-肾上腺素能受体拮抗剂）或生理盐水（对照组）。排汗率作为相对（最大工作量的百分比）和绝对运动强度的函数进行评估。训练男性运动时，心得安部位出汗率低于对照组，分别为80（0.57±0.21和0.45±0.19 mg·cm-2·min-1）和90%(0.74±0.22和0.65±0.17 mg·cm-2·min-1)，均P < 0.05。在相同的绝对强度下，训练男性在运动时的对照部位出汗率高于未训练男性，分别为160（训练和未训练分别为0.23±0.20和0.04±0.05 mg·cm-2·min-1）和180 W(0.40±0.20和0.13±0.13 mg·cm-2·min-1) （P均为0.05）。我们表明，β-肾上腺素能机制确实在运动中以亚最大的相对高强度调节习惯训练的男性的出汗。β-肾上腺素能机制可能在一定程度上有助于习惯训练的男性在运动过程中比未经训练的男性产生更多的汗液。新的和值得注意的是，我们首次证明了β-肾上腺素能机制在人体体内通过局部β-肾上腺素能受体阻断来调节运动期间的出汗（即β-肾上腺素能出汗）。β-肾上腺素能性出汗在习惯训练的个体在次最大高相对强度（最大工作80-90%）的运动中是明显的。这一观察结果促进了我们对运动过程中人体体温调节的理解，以及汗腺适应习惯性运动训练的机制。
The aim of the present study was to determine the β-adrenergic contribution to sweating during incremental exercise in habitually trained males. Nine habitually trained and 11 untrained males performed incremental cycling until exhaustion (20 W/min). Bilateral forearm sweat rates (ventilated capsule) were measured at two skin sites that were transdermally administered via iontophoresis with either 1% propranolol (Propranolol, a nonselective β-adrenergic receptor antagonist) or saline (Control). The sweat rate was evaluated as a function of both relative (percentage of maximum workload) and absolute exercise intensities. The sweat rate at the Propranolol site was lower than the control during exercise at 80 (0.57 ± 0.21 and 0.45 ± 0.19 mg·cm-2·min-1 for Control and Propranolol, respectively) and 90% (0.74 ± 0.22 and 0.65 ± 0.17 mg·cm-2·min-1, respectively) of maximum workload in trained males (all P 0.05). At the same absolute intensity, higher sweat rates on the control site were observed in trained males relative to the untrained during exercise at 160 (0.23 ± 0.20 and 0.04 ± 0.05 mg·cm-2·min-1 for trained and untrained, respectively) and 180 W (0.40 ± 0.20 and 0.13 ± 0.13 mg·cm-2·min-1, respectively) (all P 0.05). We show that the β-adrenergic mechanism does modulate sweating during exercise at a submaximal high relative intensity in habitually trained males. The β-adrenergic mechanism may in part contribute to the greater sweat production in habitually trained males than in untrained counterparts during exercise.NEW & NOTEWORTHY We demonstrated for the first time that the β-adrenergic mechanism does modulate sweating (i.e., β-adrenergic sweating) during exercise using a localized β-adrenoceptor blockade in humans in vivo. β-Adrenergic sweating was evident in habitually trained individuals during exercise at a submaximal high relative intensity (80-90% maximal work). This observation advances our understanding of human thermoregulation during exercise and of the mechanism that underlies sweat gland adaptation to habitual exercise training.