Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers
Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers
复制标题
DOI：
10.1016/j.pbb.2007.04.010
复制
发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Lu, Lin
中科院分区：
文献类型：
--
作者：
Shi, Jie;Zhao, Li-Yan;Lu, Lin
背景资料：海洛因使用停止后可能会出现持久性戒断（PA）综合征，包括渴求、消极情绪和生理变化。PA症状很少被比较无药物和美沙酮维持前海洛因使用者后，类似长度的海洛因abstines.Methods：七十前海洛因使用者被列入四组之一：美沙酮维持治疗第15-45天（短期MMT），MMT的第5-6个月（长期MMT），美沙酮辅助海洛因脱毒后15-45天无阿片类药物（短期美沙酮后）和美沙酮辅助海洛因脱毒后5-6个月无阿片类药物（长期美沙酮后）。PA症状（消极情绪，精神障碍，躯体化，渴望），血压和脉搏进行了评估前和后中性录像带和前和后海洛因videotape.Results：精神障碍和总PA评分最差的短期后美沙酮参与者，情绪最好的长期MMT参与者，和线索诱导的渴望是最不严重的长期MMT参与者。血压和脉搏并没有不同groups.Conclusions：即使在急性戒断后，第一个月的海洛因戒断后美沙酮辅助戒毒可能是更困难的线索诱导的渴望和其他PA症状比第一个月的海洛因戒断在MMT。我们的研究结果增加了支持MMT预防线索诱导的海洛因渴求的文献。(c)2007年爱思唯尔公司All rights reserved.
Background: Cession of heroin use may be followed by a protracted-abstinence (PA) syndrome consisting of craving, negative mood, and physiological changes. PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence.Methods: Seventy former heroin users were included in one of four groups: in day 15-45 of methadone maintenance therapy (short-term MMT), in month 5-6 of MMT (long-term MMT), opiate-free for 15-45 days after methadone-assisted heroin detoxification (short-term post-methadone), and opiate-free for 5-6 months after methadone-assisted heroin detoxification (long-term post-methadone). PA symptoms (negative mood, dyssomnia, somatization, and craving), and blood pressure and pulse were assessed pre- and post-neutral videotape and pre- and post-heroin videotape.Results: Dyssomnia and the total PA score were worst in short-term post-methadone participants, mood was best in long-term MMT participants, and cue-induced craving was least severe in long-term MMT participants. Blood pressure and pulse did not differ across groups.Conclusions: Even after acute withdrawal, the first months of heroin abstinence after methadone-assisted detoxification may be more difficult in terms of cue-induced craving and other PA symptoms than the first months of heroin abstinence during MMT. Our findings add to the literature supporting MMT for prevention of cue-induced heroin craving. (c) 2007 Elsevier Inc. All rights reserved.