Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.
Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.
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白介素-33促进肠球毒细胞从肠道稳态中释放5-羟色胺。
DOI：
10.1016/j.immuni.2020.10.014
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发表时间：
2021-01-12
期刊：
影响因子：
32.4
通讯作者：
Wu C
中科院分区：
文献类型：
--
作者：
Chen Z;Luo J;Li J;Kim G;Stewart A;Urban JF Jr;Huang Y;Chen S;Wu LG;Chesler A;Trinchieri G;Li W;Wu C
The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to constant environmental challenges. Enterochromaffin (EC) cells which function as chemosensors on the gut epithelium are known to translate environmental cues into serotonin (5-HT) production, contributing to intestinal physiology. However, how immune signals participate in gut sensation and neuroendocrine response remains unclear. Interleukin-33 (IL-33) act as an alarmin cytokine by alerting the system of potential environmental stresses. We here demonstrate that IL-33 induced instantaneous peristaltic movement and facilitated Trichuris muris expulsion. We found that IL-33 could be sensed by EC cells, inducing release of 5-HT. IL-33-mediated 5-HT release activated enteric neurons, subsequently promoting gut motility. Mechanistically, IL-33 triggered calcium influx via a non-canonical signaling pathway specifically in EC cells to induce 5-HT secretion. Our data establish an immune-neuroendocrine axis in calibrating rapid 5-HT release for intestinal homeostasis. Enterochromaffin (EC) cells are known to act as chemosensors on the gut epithelium, translating environmental cues into serotonin (5-HT) production. Chen et al demonstrate that an alarmin cytokine IL-33 could be sensed by EC cells, inducing release of 5-HT, regulating intestinal homeostasis and host defense.
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影响因子：
4.4
作者：
Kurowska-Stolarska, Mariola;Kewin, Pete;Xu, Damo
通讯作者：
Xu, Damo
Interleukin-33 介导福尔马林诱导的小鼠炎症性疼痛
影响因子：
3.3
作者：
Han, P.;Zhao, J.;Mi, W. -L.
通讯作者：
Mi, W. -L.
DOI：
10.1073/pnas.1804938115
发表时间：
2018-08-07
影响因子：
11.1
作者：
Alcaino C;Knutson KR;Treichel AJ;Yildiz G;Strege PR;Linden DR;Li JH;Leiter AB;Szurszewski JH;Farrugia G;Beyder A
通讯作者：
Beyder A
影响因子：
82.9
作者：
Launay, JM;Hervé, P;Maroteaux, L
通讯作者：
Maroteaux, L
影响因子：
64.5
作者：
Bellono NW;Bayrer JR;Leitch DB;Castro J;Zhang C;O'Donnell TA;Brierley SM;Ingraham HA;Julius D
通讯作者：
Julius D