Novel approach to evaluating breast density utilizing ultrasound tomography
Novel approach to evaluating breast density utilizing ultrasound tomography
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DOI：
10.1118/1.2428408
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发表时间：
2007-02-01
期刊：
影响因子：
3.8
通讯作者：
Littrup, Peter
中科院分区：
文献类型：
--
作者：
Glide, Card;Duric, Nebojsa;Littrup, Peter
与乳房脂肪过多的女性相比，乳房 X 光检查乳房密度高的女性患乳腺癌的风险增加四到五倍。许多预防策略试图将乳房密度的变化与药物和饮食等干预措施的反应联系起来。这项工作的目的是研究通过超声断层扫描声速测量来评估乳腺密度的可行性，并将结果与现有的乳房 X 线摄影乳腺密度测量结果进行比较。首先使用我们的计算机超声断层扫描临床原型对拟人化乳腺组织模型进行成像。声速与材料密度、声速与计算机断层扫描数之间观察到强正相关性（皮尔逊相关系数分别=0.87 和 0.91）。随后对 48 名女性进行了成像。通过创建图像堆栈并评估声速频率分布来确定整个乳房的声速。通过将这些结果与两种乳房 X 光密度测量进行比较来评估乳房密度的声学测量：(1) 由经过认证的放射科医生使用基于 1（脂肪）到 4（致密）等级的 BI-RADS 分类评估确定的定性估计值，以及 (2) 通过存档乳房 X 光照片的数字化和计算机分析进行定量测量。单向方差分析显示，根据 BI-RADS 类别，声速平均值之间存在显着差异，而使用 Scheffe 显着性标准的事后分析表明，在 0.05 的 alpha 水平下，BI-RADS 4（密集）患者的声速显着高于 Bl-RADS 1、2 和 3。使用乳腺密度的定量测量，平均声速与计算的乳腺X线照相百分比乳腺密度之间存在直接相关性，相关系数范围为0.75至0.89。这里提出的结果支持这样的假设：声速可以用作乳腺组织密度的指标。现在可以对影响乳腺密度的饮食和化学预防干预措施进行无创、非电离监测。 (c) 2007 年美国医学物理学家协会。
Women with high mammographic breast density have a four-to fivefold increased risk of developing breast cancer compared to women with fatty breasts. Many preventative strategies have attempted to correlate changes in breast density with response to interventions including drugs and diet. The purpose of this work is to investigate the feasibility of assessing breast density with acoustic velocity measurements with ultrasound tomography, and to compare the results with existing measures of mammographic breast density. An anthropomorphic breast tissue phantom was first imaged with our computed ultrasound tomography clinical prototype. Strong positive correlations were observed between sound speed and material density, and sound speed and computed tomography number (Pearson correlation coefficients =0.87 and 0.91, respectively). A cohort of 48 women was then imaged. Whole breast acoustic velocity was determined by creating image stacks and evaluating the sound speed frequency distribution. The acoustic measures of breast density were evaluated by comparing these results to two mammographic density measures: (1) qualitative estimates determined by a certified radiologist using the BI-RADS Categorical Assessment based on a 1 (fatty) to 4 (dense) scale, and (2) quantitative measurements via digitization and computerized analysis of archival mammograms. A one-way analysis of variance showed that a significant difference existed between the mean values of sound speed according to BI-RADS category, while post hoc analyses using the Scheffe criterion for significance indicated that BI-RADS 4 (dense) patients had a significantly higher sound speed than Bl-RADS 1, 2, and 3 at an alpha level of 0.05. Using quantitative measures of breast density, a direct correlation between the mean acoustic velocity and calculated mammographic percent breast density was demonstrated with correlation coefficients ranging from 0.75 to 0.89. The results presented here support the hypothesis that sound speed can be used as an indicator of breast tissue density. Noninvasive, nonionizing monitoring of dietary and chemoprevention interventions that affect breast density are now possible. (c) 2007 American Association of Physicists in Medicine.