Confounding and interaction effect of Treponema denticola salivary carriage in chronic periodontitis
Confounding and interaction effect of Treponema denticola salivary carriage in chronic periodontitis
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DOI：
10.1111/j.1601-0825.2009.01639.x
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发表时间：
2010-04-01
期刊：
影响因子：
3.8
通讯作者：
Tobon-Arroyave, S. I.
中科院分区：
文献类型：
--
作者：
Martinez-Pabon, M. C.;Martinez-Gaviria, A.;Tobon-Arroyave, S. I.
目的：评估唾液携带密螺旋体denticola和其与人口统计学变量的发病机制的慢性牙周炎。主题和方法：97慢性牙周炎（CP）患者和对照组51名健康受试者（HC）被选中。牙周状况的评估标准的基础上探测深度，附着丧失，程度和牙周破裂的严重程度。采用聚合酶链反应方法检测T。唾液样本中的齿垢CP的风险指标进行了单独评估，并调整混杂和/或交互使用logistic回归model.Results：虽然单变量分析显示，年龄>= 30岁，吸烟，唾液携带T。logistic回归分析显示，年龄>= 30岁/吸烟与CP之间的相关性持续存在，而唾液携带T.齿垢未能达到统计学显著性。结论：虽然唾液携带T。齿垢可能是CP的一个危险指标，但其致病性不应仅限于唾液中的检测，而可能与细菌与易感宿主的某些人口统计学特征的协同生物学相互作用有关。
Aim:To evaluate the salivary carriage of Treponema denticola and its association with demographic variables in the etiopathogenesis of chronic periodontitis.Subjects and methods:Ninety-seven chronic periodontitis (CP) patients and a control group of 51 healthy subjects (HC) were selected. Periodontal status was assessed by criteria based on probing depth, attachment loss, extent, and severity of periodontal breakdown. A polymerase chain reaction method was used to determine the occurrence of T. denticola in saliva samples. Risk indicators for CP were assessed individually and adjusted for confounding and/or interaction using a logistic regression model.Results:Although univariate analysis revealed a positive association of age >= 30 years, smoking, and salivary carriage of T. denticola with CP, after logistic regression analysis, the association between age >= 30 years/smoking and CP persisted, whereas salivary carriage of T. denticola failed to achieve statistical significance. An interaction effect was significantly detected between these three variables.Conclusion:Although salivary carriage of T. denticola may be a risk indicator for CP, its pathogenicity should not be exclusively endorsed to its detection in saliva, but it might be associated with the synergistic biological interaction of the bacterium with some demographic characteristics of the susceptible host.