In situ production of sex steroids in human breast carcinoma
In situ production of sex steroids in human breast carcinoma
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DOI：
10.1007/s00795-007-0365-8
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发表时间：
2007-09
影响因子：
1.8
通讯作者：
Takashi Suzuki;Y. Miki;T. Moriya;J. Akahira;H. Hirakawa;N. Ohuchi;H. Sasano
中科院分区：
文献类型：
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作者：
Takashi Suzuki;Y. Miki;T. Moriya;J. Akahira;H. Hirakawa;N. Ohuchi;H. Sasano
众所周知，性激素与人类乳腺癌的生长密切相关，绝大多数乳腺癌都表达性激素受体。特别是，最近的研究表明，雌激素和雄激素是局部产生的，并在乳腺癌组织中发挥作用，而不是释放到血浆中。阻断肿瘤内雌激素的产生可能会改善浸润性乳腺癌患者的预后，因此，更好地了解乳腺癌中的性类固醇产生酶是很重要的。本文综述了近年来浸润性和原位(非侵袭性)乳腺癌中性类固醇激素的组织浓度和与雌激素[芳香酸酶、类固醇硫酸酯酶(STS)和17β-羟基类固醇脱氢酶1(17βHSD1)]和雄激素(17βHSD5和5α-还原酶)相关的酶的表达情况，并讨论了性激素在乳腺癌中的意义。
It is well known that sex steroids are closely involved in the growth of human breast carcinomas, and the great majority of breast carcinomas express sex steroid receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced and act in breast carcinoma tissues without release into plasma. Blockade of intratumoral estrogen production potentially leads to an improvement in the prognosis of invasive breast carcinoma patients, and, therefore, it is important to obtain a better understanding of sex steroid-producing enzymes in breast carcinoma. In this review, we summarize recent studies on tissue concentration of sex steroids and expression of enzymes related to intratumoral production of estrogens [aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1)], and androgens (17βHSD5 and 5α-reductase) in invasive and in situ (noninvasive) breast carcinomas, and discuss the significance of intratumoral production of sex steroids in breast carcinoma.