Synthesis of trifluoromethylthioesters from aldehydes via a visible light-promoted radical process.
Synthesis of trifluoromethylthioesters from aldehydes via a visible light-promoted radical process.
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DOI：
10.1039/d0ob01160f
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发表时间：
2020-07
影响因子：
3.2
通讯作者：
Meng-Yue Wang;Xue-Qing Zhu;Xing-Long Zhang;Rui-Li Guo;Qiong Jia;Yong-Qiang Wang
中科院分区：
文献类型：
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作者：
Meng-Yue Wang;Xue-Qing Zhu;Xing-Long Zhang;Rui-Li Guo;Qiong Jia;Yong-Qiang Wang
我们在这里报道了一种高效、经济和可扩展的三氟甲硫醇缩醛反应，通过可见光促进的自由基过程生成三氟甲硫酯。该转化具有试剂便宜、操作简单、底物范围广，特别是不涉及金属的特点。该方法已经实现了几种复杂的含醛生物活性化合物的三氟甲硫化反应，有可能成为高级合成中间体和生物活性分子后期功能化的重要工具，在药物化学中具有广泛的应用前景。
We report herein an efficient, economical, and scalable trifluoromethylthiolation of aldehydes to generate trifluoromethylthioesters via a visible light-promoted radical process. The transformation features cheap reagents, simple operation, a broad substrate scope, and especially no metal involved in the reaction. Trifluoromethylthiolations of several complex aldehyde-containing bioactive compounds have been realized; thus the approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and bioactive molecules, and should have many applications in medicinal chemistry.