Pain in Parkinson's Disease
Pain in Parkinson's Disease
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DOI：
10.1002/mds.22716
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发表时间：
2010-01-01
影响因子：
8.6
通讯作者：
Ford, Blair
中科院分区：
文献类型：
--
作者：
Ford, Blair
帕金森氏病的主要特征是一种神经退行性疾病，导致运动和认知障碍。PD作为一种引起各种疼痛综合征的疾病，虽然PD中疼痛的患病率约为40%，但并不被广泛认识。在少数患者中，疼痛是如此严重和顽固，以至于它掩盖了这种疾病的运动症状。近年来，对帕金森病非运动症状的描述性调查已将疼痛感觉分为以下几类中的一种或多种：肌肉骨骼疼痛、神经根性或神经性疼痛、肌张力障碍相关疼痛、静坐不能不适和原发性中枢性帕金森病疼痛。本文综述了疼痛性PD的诊断和治疗框架，以及最近对PD疼痛的神经生理机制和底物的认识。(C)2010年运动障碍协会
Parkinson's disease is characterized primarily as a neurodegenerative disorder that leads to disabling motor and cognitive impairment. PD is less widely appreciated as a disease causing a substantial variety of pain syndromes, although the prevalence of pain in PD is approximately 40%. In a minority of patients, pain is so severe and intractable that it overshadows the motor symptoms of the disorder. In recent years, descriptive surveys of non-motor symptoms in PD have led to a classification of painful sensations into one or more of several categories: musculoskeletal pain, radicular or neuropathic pain, dystonia-related pain, akathitic discomfort, and primary, central parkinsonian pain. A framework for diagnosing and treating painful PD is described in this review, together with recent insights into the neurophysiological mechanisms and substrates of pain in PD. (C) 2010 Movement Disorder Society