Does vitamin-D intake during resistance training improve the skeletal muscle hypertrophic and strength response in young and elderly men? - a randomized controlled trial.
Does vitamin-D intake during resistance training improve the skeletal muscle hypertrophic and strength response in young and elderly men? - a randomized controlled trial.
复制标题
DOI：
10.1186/s12986-015-0029-y
复制
发表时间：
2015
影响因子：
4.5
通讯作者：
Langberg H
中科院分区：
文献类型：
--
作者：
Agergaard J;Trøstrup J;Uth J;Iversen JV;Boesen A;Andersen JL;Schjerling P;Langberg H
最近的研究表明，维生素D的摄入可以改善维生素D缺乏的虚弱人群的骨骼肌功能和力量。我们调查了摄入维生素D是否可以改善健康年轻人和老年人对阻力训练的肌肉反应。健康的未经训练的年轻男性(n = 20，年龄20-30)和老年男性(n = 20，年龄60-75)被随机分为16周，在一段时间内，在低阳光纬度(12-4月，56°N)下补充48μg维生素D + 800 mg钙(维生素D组)或800 mg钙(安慰剂组)。在补充的最后12周内，受试者接受了股四头肌的渐进性阻力训练。用横截面积(CSA)和股四头肌等长肌力的变化来测量肌肉肥大。分析肌肉活检组织中维生素D受体(VDR)、细胞色素P450 27B1(CYP27B1)和肌肉生长抑素(Myostatin)的表达和纤维类型的形态变化。在维生素D组中，血清25(OH)D浓度显著升高，12周时青年男性(71.6nmol/L)和老年男性(111.2)与安慰剂组(分别为50.4nmol/L和66.7nmol/L)均有显著差异。经过12周的抗阻训练，年轻组(CsA p <； 0.0001，力量p = 0.005)和老年组(CsA p = 0.001，力量p <； 0.0001)的股四头肌CsA和等长力量较基线增加，而维生素D组和安慰剂组之间没有差异。与年轻人相比，维生素D摄入和耐力训练增加了老年人的力量/环孢素A(p = 0.008)。在年轻的维生素D组，训练12周后IIa型纤维百分比的变化比安慰剂组更大(p = 0.030)，Myostatin mRNA的表达低于安慰剂组(p = 0.006)。抗阻训练和维生素D摄入都不会改变VDR基因的表达。在12周的抗阻训练中，维生素D摄入量对整体肌肉肥大和肌力均无相加效应，但改善了老年人的肌肉质量和年轻人的肌纤维型形态，提示维生素D对骨骼肌重塑有影响。Nr的临床试验。本文的在线版本(doi：10.1186/s12986-0150029-y)包含补充材料，授权用户可以使用。
Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. We investigated whether vitamin-D intake can improve the muscular response to resistance training in healthy young and elderly individuals, respectively. Healthy untrained young (n = 20, age 20–30) and elderly (n = 20, age 60–75) men were randomized to 16 weeks of daily supplementary intake of either 48 μg of vitamin-D + 800 mg calcium (Vitamin-D-group) or 800 mg calcium (Placebo-group) during a period and at a latitude of low sunlight (December-April, 56°N). During the last 12 weeks of the supplementation the subjects underwent progressive resistance training of the quadriceps muscle. Muscle hypertrophy, measured as changes in cross sectional area (CSA), and isometric strength of the quadriceps were determined. Muscle biopsies were analyzed for fiber type morphology changes and mRNA expression of vitamin-D receptor (VDR), cytochrome p450 27B1 (CYP27B1) and Myostatin. In the vitamin-D groups, serum 25(OH)D concentration increased significantly and at week 12 was significantly different from placebo in both young men (71.6 vs. 50.4 nmol/L, respectively) and elderly men (111.2 vs. 66.7 nmol/L, respectively). After 12 weeks of resistance training, quadriceps CSA and isometric strength increased compared to baseline in young (CSA p < 0.0001, strength p = 0.005) and elderly (CSA p = 0.001, strength p < 0.0001) with no difference between vitamin-D and placebo groups. Vitamin-D intake and resistance training increased strength/CSA in elderly compared to young (p = 0.008). In the young vitamin-D group, the change in fiber type IIa percentage was greater after 12 weeks training (p = 0.030) and Myostatin mRNA expression lower compared to the placebo group (p = 0.006). Neither resistance training nor vitamin-D intake changed VDR mRNA expression. No additive effect of vitamin-D intake during 12 weeks of resistance training could be detected on either whole muscle hypertrophy or muscle strength, but improved muscle quality in elderly and fiber type morphology in young were observed, indicating an effect of vitamin-D on skeletal muscle remodeling. ClinicalTrials with nr. NCT01252381 The online version of this article (doi:10.1186/s12986-015-0029-y) contains supplementary material, which is available to authorized users.