Hypothesis: Hyperstructures regulate bacterial structure and the cell cycle
Hypothesis: Hyperstructures regulate bacterial structure and the cell cycle
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DOI：
10.1016/s0300-9084(00)87177-1
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发表时间：
1999-08-01
期刊：
影响因子：
3.9
通讯作者：
Wiggins, P
中科院分区：
文献类型：
--
作者：
Norris, V;Alexandre, S;Wiggins, P
无数不同的成分或元素（基因、蛋白质、脂质、离子、小分子等）参与许多物理化学过程，以创造能够适应其环境生存，生长并通过细胞周期繁殖的细菌。我们探讨的可能性，这是太难解释细胞周期的进展，在这些元素和中间层次的解释是必要的。这个层次就是超结构。超结构很大，通常有一个特定的功能，并包含许多元素。例如，组装以运输和代谢营养物的非平衡或甚至耗散的超结构可以包括转运蛋白的膜结构域加上细胞质代谢子加上编码超结构的酶的基因。参与超结构形成的过程包括：代谢物诱导的蛋白质亲和力变化，导致代谢子形成，脂质组织力，导致横向和横向不对称，翻译后修饰，水结构的平衡，可能会改变其他分子的分布，transertion，离子流，电磁辐射和长距离机械振动的发射。平衡超结构也可能存在，例如以双折射液晶形式的DNA拓扑阵列。我们在这里提出了一个细菌细胞的超结构的形式，以最大限度地提高效率和超结构的属性驱动细胞周期的图片的开始。(C)1999年法国生物化学和生物分子学会/科学和医学版Elsevier SAS。
A myriad different constituents or elements (genes, proteins, lipids, ions, small molecules etc.) participate in numerous physico-chemical processes to create bacteria that can adapt to their environments to survive, grow and, via the cell cycle, reproduce. We explore the possibility that it is too difficult to explain cell cycle progression in terms of these elements and that an intermediate level of explanation is needed. This level is that of hyperstructures. A hyperstructure is large, has usually one particular function, and contains many elements. Non-equilibrium, or even dissipative, hyperstructures that, for example, assemble to transport and metabolize nutrients may comprise membrane domains of transporters plus cytoplasmic metabolons plus the genes that encode the hyperstructure's enzymes. The processes involved in the putative formation of hyperstructures include: metabolite-induced changes to protein affinities that result in metabolon formation, lipid-organizing forces that result in lateral and transverse asymmetries, post-translational modifications, equilibration of water structures that may alter distributions of other molecules, transertion, ion currents, emission of electromagnetic radiation and long range mechanical vibrations. Equilibrium hyperstructures may also exist such as topological arrays of DNA in the form of cholesteric liquid crystals. We present here the beginning of a picture of the bacterial cell in which hyperstructures form to maximize efficiency and in which the properties of hyperstructures drive the cell cycle. (C) 1999 Societe francaise de biochimie et biologie moleculaire/Editions scientifiques et medicales Elsevier SAS.