Sufficient Cause Representation of the Four-way Decomposition for Mediation and Interaction.

Sufficient Cause Representation of the Four-way Decomposition for Mediation and Interaction.
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中介和相互作用四向分解的充分原因表示。

DOI:
10.1097/ede.0000000000000521
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发表时间:
2016
期刊:
Epidemiology (Cambridge, Mass.)
影响因子:
--
通讯作者:
Shrier,Ian
Shrier,Ian
中科院分区:
--
文献类型:
--
作者:
VanderWeele,TylerJ;Shrier,Ian

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最近的工作1表明,如何曝光的结果,在一个调解人的上下文中,曝光可能会相互作用,可以分解为四个组成部分:由于公正的调解,由于公正的互动,由于调解和互动,以及由于既不调解也不互动。在这封研究信中,我们展示了这四个组成部分中的每一个如何在允许调解的充分原因框架内表达。2,3设A为暴露,M为中介,Y为结果。为了简单起见,我们考虑A、M和Y都是二进制的情况。在反事实框架内,我们将Ya定义为如果A被设置为a,我们会观察到的结果Y。总效应由Y1-Y 0定义。我们将Yam定义为潜在结果Y,如果A被设置为a,M被设置为m。我们将Ma定义为如果A被设置为a的潜在结果M。我们假设Ya= Y,
Recent work1 has shown how a total effect of an exposure on an outcome, in the context of a mediator with which the exposure might interact, could be decomposed into four components: that due to just mediation, that due to just interaction, that due to both mediation and interaction, and that due to neither mediation nor interaction. In this research letter, we show how each of these four components can be expressed within the sufficient cause framework allowing for mediation. 2, 3 Let A be an exposure, M a mediator, and Y an outcome. For simplicity, we consider the case in which A, M, and Y are all binary. Within the counterfactual framework, we define Ya as the outcome Y we would have observed if A had been set to a. the total effect is defined by Y1–Y0. We define Yam as the potential outcome Y if A were set to a, and M were set to m. We define Ma as the potential outcome M if A were set to a. We make consistency assumptions that Ya= Y and
DOI: 10.1093/aje/kwm179
发表时间: 2007-11-01
影响因子: 5
作者:
VanderWeele, Tyler J.;Robins, James M.
通讯作者: Robins, James M.