Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
复制标题
DOI：
10.1093/eurheartj/ehn573
复制
发表时间：
2009-04-01
影响因子：
39.3
通讯作者：
Hoffmann, Udo
中科院分区：
文献类型：
--
作者：
Mahabadi, Amir A.;Massaro, Joseph M.;Hoffmann, Udo
本研究的目的是评估心包脂肪、胸内脂肪和内脏腹部脂肪组织（VAT）是否与心血管疾病（CVD）的患病率相关。来自FracheartStudyOffspring队列的参与者接受腹部和胸部多探测器计算机断层扫描，以量化心包脂肪、胸内脂肪和VAT的体积。使用逻辑回归评估每个脂肪库和CVD之间的关系。1267名参与者的分析（平均年龄60岁，53.8%的女性，9.7%的CVD患者）证实心包脂肪[比值比（OR）1.32，95%置信区间（CI）1.11-1.57; P = 0.002]和VAT（OR 1.35，95%CI 1.11-1.57; P = 0.003），而不是胸内脂肪（OR 1.14，95%CI 0.93-1.39; P = 0.22），与年龄-性别校正模型中以及校正体重指数和腰围后的CVD患病率显著相关。经多因素校正后，相关性减弱（P > 0.14）。在调整了传统的肥胖指标后，只有心包脂肪与心肌梗死相关（OR 1.37，95%CI 1.03-1.82; P = 0.03），心包脂肪和VAT与CVD相关，而胸内脂肪与CVD无关，与传统的肥胖指标无关，但在进一步调整传统的危险因素后，与CVD无关。结合我们先前的工作，这些发现可能支持心包脂肪促进冠状动脉粥样硬化的假设。
The aim of this study was to assess whether pericardial fat, intrathoracic fat, and visceral abdominal adipose tissue (VAT) are associated with the prevalence of cardiovascular disease (CVD).Participants from the Framingham Heart Study Offspring cohort underwent abdominal and chest multidetector computed tomography to quantify volumes of pericardial fat, intrathoracic fat, and VAT. Relations between each fat depot and CVD were assessed using logistic regression. The analysis of 1267 participants (mean age 60 years, 53.8% women, 9.7% with prevalent CVD) demonstrated that pericardial fat [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.11-1.57; P = 0.002] and VAT (OR 1.35, 95% CI 1.11-1.57; P = 0.003), but not intrathoracic fat (OR 1.14, 95% CI 0.93-1.39; P = 0.22), were significantly associated with prevalent CVD in age-sex-adjusted models and after adjustment for body mass index and waist circumference. After multivariable adjustment, associations were attenuated (P > 0.14). Only pericardial fat was associated with prevalent myocardial infarction after adjusting for conventional measures of adiposity (OR 1.37, 95% CI 1.03-1.82; P = 0.03).Pericardial fat and VAT, but not intrathoracic fat, are associated with CVD independent of traditional measures of obesity but not after further adjustment for traditional risk factor. Taken together with our prior work, these findings may support the hypothesis that pericardial fat contributes to coronary atherosclerosis.