The effects of active and passive stimulation on chemosensory event-related potentials
The effects of active and passive stimulation on chemosensory event-related potentials
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DOI：
10.1016/s0167-8760(96)00061-x
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发表时间：
1996-10-01
影响因子：
3
通讯作者：
Bryant, DN
中科院分区：
文献类型：
--
作者：
Lorig, TS;Matia, DC;Bryant, DN
在正常嗅觉过程中，刺激取决于鼻吸气。在收集化学感应事件相关电位 (CSERP) 时，吸入可能会产生伪影，例如与呼吸相关的脑电位，从而混淆数据的解释。为了避免这种类型的伪影，通常使用独立于呼吸周期的刺激来收集 CSERP。然而，灵感有可能为嗅觉输入做好准备，而传统的 CSERP 数据采集技术掩盖了这种神经准备。为了研究这个问题，十二名受试者使用两种不同的刺激方法进行了测试。将气味剂（2% 和 4% 丁醇）引入温暖湿润的气流中，并通过插管输送到一个鼻孔。在一种情况下，受试者用嘴呼吸，刺激与呼吸周期异步发生（被动）。在另一种情况下，受试者通过鼻子吸气，刺激与鼻吸气同步传递（主动）。 CSERP 数据是在刺激后 3 秒内从 30 个头皮部位收集的。数据针对眼球运动进行了校正、平滑和平均。确定早期负性 (N1) 和后期正性 (P2) 的最大振幅，并进行单独的方差分析。这些分析表明，给药技术与气味浓度和记录位点相互作用。此外，被动条件下 P2 的幅度更大。这些结果表明，两种给药技术对嗅觉刺激产生不同的神经处理，并且被动技术由于其幅度较大，可能更适合确定单个受试者嗅道的完整性。
During normal olfaction, stimulation is dependent upon nasal inhalation. When collecting chemosensory event-related potentials (CSERPs), inhalations may produce artifacts such as respiration-related brain potentials that confound interpretation of the data. To avoid this type of artifact, CSERPs have often been collected using stimulation that is independent of respiratory cycle. It is possible, however, that inspirations prime the olfactory tract for odor input, and traditional CSERP data acquisition techniques obscure this neural preparation. To investigate this question, twelve subjects were tested using two different approaches to stimulation. Odorants (butanol 2% and 4%) were introduced into a warmed and humidified air stream and delivered to one nostril through a cannula. In one condition, subjects mouth-breathed and stimuli occurred asynchronously with respiratory cycle (passive). In the other condition, subjects inhaled through the nose and stimuli were delivered synchronously with nasal inhalations (active). CSERP data were collected from thirty scalp sites for 3 s following stimulation. Data were corrected for eye movements, smoothed, and averaged. Maximal amplitudes for an early negativity (N1) and later positivity (P2) were determined and submitted to separate analyses of variance. These analyses indicated that administration technique interacted with both odor concentration and recording site. Additionally, amplitude of P2 was greater in the passive condition. Such results suggest that the two administration techniques produce different neural processing of olfactory stimuli and that the passive technique may be better suited for determination of the integrity of the olfactory tract for single subjects because of its greater amplitude.