Chemoprevention of cancer
Chemoprevention of cancer
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DOI：
10.1093/carcin/21.3.525
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发表时间：
2000-03-01
期刊：
影响因子：
4.7
通讯作者：
Suh, N
中科院分区：
文献类型：
--
作者：
Sporn, MB;Suh, N
在这篇短文中，我们回顾了癌症化学预防的概念基础、该概念已被证实的临床功效，以及基于了解其作用机制开发新化学预防药物的当前趋势。详细讨论了四类新药物，即选择性环氧合酶-2抑制剂、选择性雌激素受体调节剂、类维生素A（选择性结合RXR受体的类维生素A）和过氧化物酶体增殖物激活受体-γ的配体。强调了开发全新类别化学预防剂的重要性，特别强调了源自天然分子的新型合成三萜类化合物的潜在用途。
In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemo-preventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor modulators, rexinoids (retinoids that bind selectively to the receptors known as RXRs) and ligands for the peroxisome proliferator-activated receptor-gamma are discussed in detail. The importance of developing totally new classes of chemopreventive agents is stressed, with particular emphasis on the potential usefulness of new synthetic triterpenoids derived from naturally occurring molecules.