Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease.
Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease.
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DOI：
10.1196/annals.1427.038
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Shi Q
中科院分区：
文献类型：
--
作者：
Gibson GE;Karuppagounder SS;Shi Q
大量数据支持线粒体异常将基因缺陷和/或环境损伤与神经退行性过程联系起来的假设。氧化剂与钙和三羧酸（TCA）循环的线粒体酶的相互作用是这种关系的核心。在阿尔茨海默病 (AD) 患者的大脑或成纤维细胞中发现的异常现象已在体外和体内建模，以评估其病理生理学重要性并确定如何逆转它们。这些结论与 AD 相关异常是由氧化应激引起的假设一致。用于逆转的化合物的选择很复杂，因为相关化合物的作用在不同条件下（例如细胞氧化还原状态以及急性与慢性变化）会有所不同。然而，已开发的模型可用于测试潜在药物的有效性。结果表明，线粒体缺陷的逆转和氧化应激的减少将减少临床和病理变化，并使患者受益。
Considerable data supports the hypothesis that mitochondrial abnormalities link gene defects and/or environmental insults to the neurodegenerative process The interaction of oxidants with calcium and the mitochondrial enzymes of the tricarboxylic acid (TCA) cycle are central to that relationship. Abnormalities that were discovered in brains or fibroblasts from patients with Alzheimer's Disease (AD) have been modeled in vitro and in vivo to assess their pathophysiological importance and to determine how they might be reversed. The conclusions are consistent with the hypothesis that the AD-related abnormalities result from oxidative stress. The selection of compounds for reversal is complex because the actions of the relevant compounds vary under different conditions such as cell redox states and acute vs chronic changes. However, the models that have been developed are useful for testing the effectiveness of the potential medications. The results suggest that the reversal of the mitochondrial deficits and a reduction in oxidative stress will reduce the clinical and pathological changes and benefit patients.
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影响因子：
2.9
作者：
Humphries, KM;Yoo, Y;Szweda, LI
通讯作者：
Szweda, LI
DOI：
10.1016/s0925-4439(01)00091-6
发表时间：
2002-03-16
影响因子：
6.2
作者：
Gibson, GE;Zhang, H;Jeitner, TM
通讯作者：
Jeitner, TM
影响因子：
4.7
作者：
Calingasan, NY;Uchida, K;Gibson, GE
通讯作者：
Gibson, GE
影响因子：
4.7
作者：
Chinopoulos, C;Tretter, L;Adam-Vizi, V
通讯作者：
Adam-Vizi, V
影响因子：
2.9
作者：
Humphries, KM;Szweda, LI
通讯作者：
Szweda, LI