Oxidative modification of low-density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome
Oxidative modification of low-density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome
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DOI：
10.1203/pdr.0b013e3181647af5
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Sayed, Mohmed M.
中科院分区：
文献类型：
--
作者：
El-Melegy, Nagla T.;Mohamed, Nagwa A.;Sayed, Mohmed M.
有研究认为，肾病综合征是氧化/抗氧化状态失衡的结果。本研究旨在评估激素敏感型肾病综合征(SSNS)缓解期和复发期儿童的氧化和抗氧化状态与血脂异常的关系。这项研究涉及40名被诊断为SSNS的儿童。他们被分成两个亚组。第一组包括25名缓解期儿童。第二组包括15名复发儿童。对照组为年龄、性别匹配的15名健康儿童。血清丙二醛、氧化低密度脂蛋白、总胆固醇、低密度脂蛋白、甘油三酯、载脂蛋白A-I和载脂蛋白-B水平在SSNS患者中显著升高，尤以复发者为甚。患者的血清白蛋白、谷胱甘肽过氧化物酶活性、维生素C、A、E和高密度脂蛋白胆固醇水平显著降低，尤其是在复发者中。总之，在SSNS患者中，特别是在复发者中，氧化/抗氧化状态与血脂异常之间有很强的相关性。尽管使用了糖皮质激素，但生化指标并未恢复正常。因此，可推荐在此类儿童中联合使用类固醇、抗氧化治疗和降脂治疗。
It has been proposed that nephrotic syndrome is a consequence of an imbalance between oxidant/antioxidant statuses. The present study aimed to assess oxidant and antioxidant status in relation to dyslipidemia in children during remission and relapse phases of steroid sensitive nephrotic syndrome (SSNS). The study dealt with 40 children diagnosed as SSNS. They were categorized into two subgroups. The first subgroup included 25 children during remission stage. The second subgroup included 15 children during relapse. Control group consisted of age and gender-matched 15 healthy children. Significantly higher serum levels of malondialdehyde, oxidized LDL, total cholesterol, LDL cholesterol, triglycerides, apolipoprotein A-I, and apolipoprotein-B were observed in patients with SSNS especially in the relapsers. The serum levels of albumin, glutathione peroxidase activity, vitamin C, A, and E, and HDL cholesterol were significantly lower in patients especially among relapsers. In conclusion, a strong relationship between the oxidant/ antioxidant status and dyslipidemia is documented in patients with SSNS, especially among relapsers. No normalization of the biochemical indices was observed despite the use of glucocorticoids. Therefore, the combined use of steroid, antioxidant therapy, and lipid lowering therapy can be recommended in such children.