Immunohistochemical expression of EGFR and p-EGFR in oral squamous cell carcinomas
Immunohistochemical expression of EGFR and p-EGFR in oral squamous cell carcinomas
复制标题
DOI：
10.1007/bf02893450
复制
发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Fujita, Shigeyuki
中科院分区：
文献类型：
--
作者：
Hiraishi, Yukihiro;Wada, Takeshi;Fujita, Shigeyuki
表皮生长因子受体（EGFR）是ErbB家族的酪氨酸激酶受体，在包括口腔癌在内的多种实体瘤中表达或高表达。高 EGFR 表达与肿瘤大小、转移和生存相关。近年来，EGFR被认为是单克隆抗体治疗的一个有前景的靶点。共选取52例口腔鳞状细胞癌（OSCC）患者进行EGFR和磷酸化EGFR（p-EGFR）检测。进行免疫组织化学染色以评估 EGFR 和 p-EGFR 表达。所有病例的 EGFR 和 p-EGFR 染色阳性率分别为 92.3% (48/52) 和 98.0% (51/52)。所有病例中 EGFR 和 p-EGFR 的高表达率分别为 63.4% (33/52) 和 69.2% (36/52)。 EGFR和p-EGFR表达与临床因素肿瘤分期、区域淋巴结转移或远处转移无关。然而，EGFR 高表达与病理因素肿瘤侵袭之间存在统计学上显着的相关性。结论是，大多数 OSCC 高表达 EGFR 和 p-EGFR，表明研究针对这些信号因子的抗癌治疗功效的重要性。
Epidermal growth factor receptor ( EGFR) is a tyrosine kinase receptor of the ErbB family, which is expressed or highly expressed in a variety of solid tumors, including oral cancers. High EGFR expression has been correlated with tumor size, metastasis and survival. In recent years, EGFR has been considered a promising target for monoclonal antibody therapy. A total of 52 patients with oral squamous cell carcinoma (OSCC) were selected for EGFR and phosphorylated EGFR (p-EGFR) detection. Immunohistochemical staining was performed to evaluate EGFR and p-EGFR expression. Positive EGFR and p-EGFR staining was present in 92.3% (48/52) and 98.0% (51/52) of all cases, respectively. High EGFR and p-EGFR expression was present in 63.4% (33/52) and 69.2% (36/52) of all cases, respectively. EGFR and p-EGFR expression did not correlate with the clinical factors tumor stage, regional lymph node metastasis, or distant metastasis. However, a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. As a conclusion, the majority of OSCCs highly express EGFR and p-EGFR, indicating the importance of studying the efficacy of anticancer therapy targeting these signal factors.