Gender-related differences in the burden of non-motor symptoms in Parkinson's disease
Gender-related differences in the burden of non-motor symptoms in Parkinson's disease
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DOI：
10.1007/s00415-011-6392-3
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发表时间：
2012-08-01
影响因子：
6
通讯作者：
Chaudhuri, Kallol Ray
中科院分区：
文献类型：
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作者：
Martinez-Martin, Pablo;Pecurariu, Cristian Falup;Chaudhuri, Kallol Ray
帕金森病(PD)患者非运动症状(NMS)表达的差异可能对其治疗和预后有重要意义。性别是一个基本的流行病学变量，可能会影响这种表达。本研究采用非运动症状量表(NMSS)对951例帕金森病患者(其中62.63%为男性)的NMS的患病率和严重程度进行了性别评估。对运动损伤和并发症、全球严重程度和健康状况的评估也被应用。所有疾病分期均包括在内。在人口统计学和临床特征方面没有发现显著的性别差异。在整个样本中，最常见的症状是夜尿(64.88%)和疲劳(62.78%)，最常见的影响领域是睡眠/疲劳(84.02%)和其他(82.44%)。疲倦、紧张、悲伤、便秘、腿不宁和疼痛在女性中更为常见和严重。相反，白天嗜睡、流口水、对性行为感兴趣以及性行为问题在男性中更为普遍和严重。关于NMSS领域，情绪/冷漠和其他问题(疼痛、味觉或嗅觉丧失、体重变化和出汗过多)主要影响女性，男性主要影响性功能障碍。没有观察到性别的其他显著差异。总而言之，在这项研究中，男性和女性在疲劳感、情绪、性和消化问题、疼痛、腿不宁和白天嗜睡的患病率和严重程度方面存在显著差异。NMS参与的性别相关模式可能与PD的临床试验相关。
Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. For the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and the most prevalent affected domains were Sleep/Fatigue (84.02%) and Miscellaneous (82.44%). Fatigue, feelings of nervousness, feelings of sadness, constipation, restless legs, and pain were more common and severe in women. On the contrary, daytime sleepiness, dribbling saliva, interest in sex, and problems having sex were more prevalent and severe in men. Regarding the NMSS domains, Mood/Apathy and Miscellaneous problems (pain, loss of taste or smell, weight change, and excessive sweating) were predominantly affected in women and Sexual dysfunction in men. No other significant differences by gender were observed. To conclude, in this study significant differences between men and women in prevalence and severity of fatigue, mood, sexual and digestive problems, pain, restless legs, and daytime sleepiness were found. Gender-related patterns of NMS involvement may be relevant for clinical trials in PD.