Ciprofloxacin-resistant ST198 Salmonella Kentucky in a hospitalized American black bear (Ursus americanus), with evidence of subsequent nosocomial transmission.
Ciprofloxacin-resistant ST198 Salmonella Kentucky in a hospitalized American black bear (Ursus americanus), with evidence of subsequent nosocomial transmission.
复制标题
一只住院的美国黑熊 (Ursus americanus) 体内存在对环丙沙星具有抗药性的 ST198 肯塔基沙门氏菌，有证据表明随后出现院内传播。
DOI：
10.1111/zph.13075
复制
发表时间：
2023
影响因子：
2.4
通讯作者：
Childs-Sanford,SaraE
中科院分区：
文献类型：
--
作者：
Cummings,KevinJ;Siler,JulieD;Goodman,LauraB;Childs-Sanford,SaraE
全球出现的耐环丙沙星st198肯塔基沙门氏菌构成了重要的公共卫生威胁。在对纽约中部兽医教学医院收治的野生动物患者进行沙门氏菌监测时，我们于2020年9月从一只美国黑熊（美洲熊）身上分离出了耐多药（MDR） st198肯塔基沙门氏菌。该分离株对头孢曲松和环丙沙星等多种抗菌素具有明显的耐药表型，并检测到多种抗菌素耐药基因和突变耐药决定因素。在2021年4月至7月期间，还从其他7名野生动物患者和多个医院环境地点分离出了相同的耐多药ST198SalmonellaKentucky菌株，这表明存在医院传播。环丙沙星耐药是由喹诺酮类药物耐药决定区（qrdr）的三点突变引起的，该基因型谱指示进化支st1982。据我们所知，这是美国首次在动物或动物产品中发现这种环丙沙星耐药分支。在努力进一步加强医院的环境消毒方案和生物安全措施后，疫情得到了及时解决，2021年7月以后没有已知病例或阳性环境样本。
Global emergence of ciprofloxacin‐resistant ST198SalmonellaKentucky poses an important public health threat. While conductingSalmonellasurveillance among wildlife patients admitted to our veterinary medical teaching hospital in central New York, we isolated multidrug‐resistant (MDR) ST198SalmonellaKentucky from an American black bear (Ursus americanus) in September 2020. The isolate was phenotypically resistant to numerous antimicrobial agents, including ceftriaxone and ciprofloxacin, and several antimicrobial resistance genes and mutational resistance determinants were detected. Between April and July 2021, the same strain of MDR ST198SalmonellaKentucky was also isolated from seven other wildlife patients and multiple hospital environmental locations, suggesting nosocomial transmission. Ciprofloxacin resistance is conferred by triple point mutations in the quinolone resistance‐determining regions (QRDRs), a genotypic profile indicative of Clade ST198.2. To our knowledge, this is the first report of this ciprofloxacin‐resistant clade being identified in animals or animal products in the United States. Timely resolution of the outbreak was achieved following efforts to further enhance environmental disinfection protocols and biosecurity measures at the hospital, with no known cases or positive environmental samples after July 2021.