Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli
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DOI：
10.1037/0735-7044.111.4.683
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发表时间：
1997-08-01
影响因子：
1.9
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Muller, J;Corodimas, KP;LeDoux, JE
在大鼠恐惧调节或测试之前，将GABAa激动剂muscimol （0.5 μ g / 0.5 μ l生理盐水）或载药注入外侧和基底杏仁核。大鼠在训练和测试前分别给予muscimol和生理盐水，而对照组在训练和测试前给予生理盐水的大鼠对条件刺激和环境的冻结程度要低得多。在训练前给予生理盐水和测试前给予muscimol的大鼠对CS和环境的冻结程度也很低。在后续程序中，最初通过预训练注射muscimol阻止获得的大鼠在重新训练和盐水注射重新测试时以与对照组相似的方式冻结。老鼠:;用生理盐水训练，但用muscimol测试，可能是条件反射，但可以表达学习。当用生理盐水重新测试时，他们和对照组一样被冻结。因此，外侧杏仁核和基底杏仁核的活动似乎在恐惧条件反射的获得和表达中起着至关重要的作用。
The GABAa agonist, muscimol (0.5 mu g in 0.5 mu l saline), or vehicle was infused into the lateral and basal amygdala nuclei prior to fear conditioning or testing in rats. Rats given muscimol before conditioning and saline before testing showed much less freezing to the conditioned stimulus (CS) and the context than did controls given saline before training and testing. Rats given saline before training and muscimol prior to testing also showed low levels of freezing to the CS and the context. In follow-up procedures, rats with acquisition initially blocked by pretraining muscimol infusions froze in a manner similar to that of controls when retrained and retested with saline infusions. Rat:; trained with saline but tested with muscimol presumably became conditioned but could express the learning. When retested with saline, they froze in the same manner as controls. Thus, activity in the lateral and basal amygdala appears to play an essential role in the acquisition and expression of fear conditioning.