Stereotactic radiosurgery for hypothalamic hamartomas.
Stereotactic radiosurgery for hypothalamic hamartomas.
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立体定向放射外科治疗下丘脑错构瘤。
DOI：
10.1055/s-2006-953548
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
B. Sutter
中科院分区：
文献类型：
--
作者：
F. Unger;O. Schröttner;M. Feichtinger;G. Boné;K. Haselsberger;B. Sutter
下丘脑错构瘤是一种非肿瘤性病变，通常以中枢性早熟和充血性癫痫为特征。由于位置的微妙，手术往往不成功，并伴随着相当大的风险。在所介绍的系列中，应用伽玛刀放射外科治疗。本文报告4例(年龄5~13岁)以难治性粘弹性癫痫为主诉，继发泛化增多，行为异常，性早熟(3例)。MRI诊断为下丘脑错构瘤，肿瘤大小11~17 mm。放射外科治疗在全身麻醉下进行，边缘剂量为12~14Gy，覆盖体积为600~2300mm3的50~90%等剂量线。随访12~68个月，癫痫发作频率和强度持续下降(按Engel评分：II a 3例，III a 1例)。所有患者都重新融入了社会。磁共振成像并未显示病变大小的显著变化。伽玛刀放射外科治疗HH是一种有效和安全的替代治疗方法，能够在特定病例中实现良好的癫痫控制和改善行为障碍。
Hypothalamic hamartomas are nonneoplastic lesions often characterized by central precocious puberty and gelastic epilepsy. Due to the delicate location surgery is often unsuccessful and associated with considerable risks. In the presented series, Gamma Knife radiosurgery was applied. Four cases (aged between 5-13 years) who presented with medically intractable gelastic epilepsy and increasing secondary generalization, abnormal behaviour and precocious puberty (3 cases) are reported. Hypothalamic hamartomas sized 11-17 mm had been diagnosed by MR imaging. Radiosurgical treatment was performed in general anaesthesia with margin doses of 12-14 Gy to the 50-90% isodoses covering volumes of 600-2300 mm3. After follow-up periods of 12 to 68 months, a continuing decrease both in seizure frequency and intensity was noted (outcome according to Engel: II a (3 cases) and III a (1 case)). All patients are socially reintegrated. MR imaging did not reveal significant changes concerning the size of the lesions. Gamma Knife radiosurgery can be an effective and safe alternative treatment modality for HH capable of achieving good seizure control and improving behavioural disorders in selected cases.
灰结节错构瘤：四例 MR 和 CT 表现的比较。
DOI：
--
发表时间：
1989
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Burton,EM;BallJr,WS;Crone,K;Dolan,LM
通讯作者：
Dolan,LM