THE RESPONSE OF 7 PROSTATIC FLUID COMPONENTS TO PROSTATIC DISEASE
THE RESPONSE OF 7 PROSTATIC FLUID COMPONENTS TO PROSTATIC DISEASE
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DOI：
10.1111/j.1365-2605.1982.tb00280.x
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
COSTELLO, CB
中科院分区：
文献类型：
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作者：
KAVANAGH, JP;DARBY, C;COSTELLO, CB
研究了人前列腺液样品（282）的pH值、Zn和柠檬酸盐浓度以及它们的酸性磷酸酶、亮氨酸氨肽酶、二胺氧化酶和β-磷酸酶。葡萄糖醛酸酶活性。根据患者的临床状况对结果进行分析。除了二胺氧化酶和β-葡萄糖氧化酶外，发现患者类别之间的显著差异。葡萄糖醛酸酶。这些差异主要存在于明显健康的前列腺和前列腺炎患者之间; pH值升高，酸性磷酸酶、亮氨酸氨肽酶、锌和柠檬酸盐降低。评价了这些参数的诊断价值，每个参数可用于正确分类这两组中90%的患者。锌、柠檬酸盐和亮氨酸氨肽酶在区分BPH和前列腺炎方面无年龄关系，优于酸性磷酸酶和pH。也有证据表明，前列腺炎发作后的某个时候，分泌功能恢复正常。锌和柠檬酸盐可能是临床评价的最有用参数。
Human prostatic fluid samples (282) were investigated for their pH value, Zn and citrate concentration and their acid phosphatase, leucine aminopeptidase, diamine oxidase and .beta.-glucuronidase activities. The results were analyzed in terms of the clinical status of the patients. Significant differences between patient categories were found with all but diamine oxidase and .beta.-glucuronidase. These differences were mainly found between men with apparently healthy prostates and prostatitis patients; the pH being raised and the acid phosphatase, leucine aminopeptidase, Zn and citrate being reduced. The diagnostic value of these parameters was evaluated, each could be used to classify correctly 90% of patients from these 2 groups. Zn, citrate and leucine aminopeptidase showed no age relationship and were better than acid phosphatase and pH in discriminating between BPH [benign prostatic hyperplasia] and prostatitis. Evidence was also found for a return of normal secretory function sometime after an episode of prostatitis. Zn and citrate are likely to be the most useful parameters for clinical evaluation.