Spread of Carbapenem-Resistant Acinetobacter baumannii Global Clone 2 in Asia and AbaR-Type Resistance Islands
Spread of Carbapenem-Resistant Acinetobacter baumannii Global Clone 2 in Asia and AbaR-Type Resistance Islands
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DOI：
10.1128/aac.00633-13
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发表时间：
2013-11-01
影响因子：
4.9
通讯作者：
Ko, Kwan Soo
中科院分区：
文献类型：
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作者：
Kim, Dae Hun;Choi, Ji-Young;Ko, Kwan Soo
在这项监测研究中，我们确定了来自9个亚洲地区的碳青霉烯类耐药鲍曼不动杆菌（CRAB）分离株的基因型、碳青霉烯类耐药决定因素和AbaR型耐药岛的结构变异。克隆复合体92（CC 92），对应于全球克隆2（GC 2），在大多数亚洲地区最流行（83/108株分离株; 76.9%）。CC 108或GC 1是印度的优势克隆。OXA-23苯唑西林酶在除台湾以外的大多数亚洲地区的CRAB分离株中检测到。bla（OXA-24）在台湾的CRAB分离株中发现。AbaR 4型耐药岛，分为6个亚型，被确定在大多数CRAB株调查。来自印度、马来西亚、新加坡和香港的5个分离株含有AbaR 3型耐药岛。其中，三个菌株同时具有AbaR 3和AbaR 4型抗性岛。在这项研究中，GC 2被发现是一个流行的克隆在大多数亚洲地区，与AbaR 4型耐药岛占主导地位，与不同的变体。本研究的意义在于确定全球碳青霉烯类耐药A.亚洲的鲍曼不动杆菌。
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. bla(OXA-24) was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3-and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.