Medial prefrontal activity during shifting under novel situations
Medial prefrontal activity during shifting under novel situations
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新情况下转换时的内侧前额叶活动
DOI：
10.1016/j.neulet.2010.08.047
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发表时间：
2010
影响因子：
2.5
通讯作者：
Miyashita Y
中科院分区：
文献类型：
--
作者：
Konishi S.;Hirose S.;Jimura K.;Chikazoe J.;Watanabe T.;Kimura H. M.;Miyashita Y
威斯康星州卡片分类测试(WCST)的神经心理学研究表明，背外侧和内侧前额叶皮质的损害会损害患者的操作能力。这项功能磁共振成像(FMRI)研究的目的是通过采用改进的WCST来探索在新情况下与换挡相关的大脑活动。WCST维度的顺序是基于受试者自己的选择而确定的，在类似的情况下，受试者更有可能在没有事先尝试改变的情况下改变。在新的情况下，第一次转换中的大脑活动与在不那么新的情况下的随后转换中的大脑活动形成对比。对比显示，大脑背外侧和前额内侧区域都有显著的脑活动。此外，在初始变化的第一个阶段，背外侧前额叶区域的脑活动显著降低，需要在较小程度上抑制主动干扰，而内侧前额叶区域在整个初始变化过程中表现出恒定的激活水平。这些结果表明内侧前额叶区域参与了WCST的移位，并提示在新的情况下，背外侧前额叶区域和内侧前额叶区域在移位过程中的不同作用。
Neuropsychological studies of the Wisconsin Card Sorting Test (WCST), where the WCST was administered to patients without prior knowledge of the test, have revealed that the performance is impaired by lesions to the dorsolateral and medial prefrontal cortex. The aim of this functional magnetic resonance imaging (fMRI) study is to explore the brain activity related to shifting under novel situations by adopting a modified WCST. The order of the WCST dimensions was determined based on the subjects’ own choice, whereby subjects were more likely to shift without prior attempt of shifting in a similar situation. The brain activity in the initial shifts under novel situations was contrasted with the brain activity in the subsequent shifts under less novel situations. The contrast revealed significant brain activity both in the dorsolateral and medial prefrontal regions. Moreover, the brain activity in the dorsolateral prefrontal region was significantly lower at the very first of the initial shifts, where inhibition of proactive interference was needed to a lesser degree, while the medial prefrontal region showed a constant activation level across the initial shifts. These results demonstrate the involvement of the medial prefrontal region in the shifting in the WCST, and suggest the differential roles of the dorsolateral and medial prefrontal regions during shifting under novel situations.