The metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies.
The metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies.
复制标题
大鼠和仓鼠体内放射性铪的代谢：用于代谢研究的可能的钚类似物。
作者：
D. Taylor;M. Lehmann;F. Planas;A. Seidel
本文研究了放射性铪（~（175）Hf +~（181）Hf）在雄性SD大鼠和中国仓鼠体内的代谢。将结果与239 Pu在同一品系大鼠中的类似数据进行了比较。在大鼠和仓鼠的放射性铪器官分布是骨骼大于皮肤大于肌肉大于肝脏在注射后约7天。放射性铪和钚在血浆和肝脏中的保留相似，其他器官的保留时间也相似：大鼠胃肠道中放射性铪的吸收小于0.05%。生物化学研究表明，放射性铪主要结合在大鼠和仓鼠的血浆和肝细胞溶质中的铁转运蛋白--转铁蛋白上，正如对钚所观察到的那样。放射性铪的代谢行为在很大程度上模仿钚的代谢行为，并且建议放射性铪可以作为钚的非α粒子发射模拟物用于代谢、生物化学和选定的人类研究。
The metabolism of radiohafnium (175Hf + 181Hf) was studied in male Sprague-Dawley rats and Chinese hamsters for periods of up to 168 days. The results were compared with similar data for 239Pu in the same rat strain. In rats and hamsters the radiohafnium organ distribution was skeleton greater than skin greater than muscle greater than liver at about 7 days postinjection. Retention of radiohafnium and plutonium was similar in plasma and liver, as were the retention times observed for other organs: Absorption of radiohafnium from the gastrointestinal tract of rats was less than 0.05%. Biochemical studies showed that the radiohafnium was bound mainly to the iron-transport protein, transferrin, in blood plasma and in the liver cytosol of both the rat and the hamster, as has been observed also for plutonium. The metabolic behavior of radiohafnium mimics, to a large extent, that of plutonium, and it is suggested that radiohafnium can serve as a non-alpha-particle-emitting analog of plutonium for metabolic, biochemical, and selected human investigations.