mTOR in health and in sickness
mTOR in health and in sickness
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DOI：
10.1007/s00109-015-1326-7
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发表时间：
2015-10-01
影响因子：
4.7
通讯作者：
Hall, Michael N.
中科院分区：
文献类型：
--
作者：
Liko, Dritan;Hall, Michael N.
雷帕霉素靶标(TOR)是一种高度保守的蛋白激酶，在调节细胞生长和动态平衡中起着关键作用。它被营养物质、生长因子和细胞能量水平激活，以控制一些合成代谢和分解代谢过程。它是一种有效的药物靶点，与多种疾病有关。在这篇综述中，我们从细胞和生物生理学的角度描述了TOR的分子作用模式。我们重点介绍哺乳动物的TOR(MTOR)信号在癌症和神经系统疾病中的作用，并讨论TOR抑制剂在临床上的使用。
Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.