Gas chromatographic-light microscopic correlative analysis of excimer laser photoablation of cardiovascular tissues: evidence for a thermal mechanism.
Gas chromatographic-light microscopic correlative analysis of excimer laser photoablation of cardiovascular tissues: evidence for a thermal mechanism.
复制标题
准分子激光光消融心血管组织的气相色谱-光显微相关分析：热机制的证据。
DOI：
10.1161/01.res.60.3.429
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发表时间：
1987
影响因子：
20.1
通讯作者：
Jones2nd,G
中科院分区：
文献类型：
--
作者：
Clarke,RH;Isner,JM;Donaldson,RF;Jones2nd,G
The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and atherosclerotic coronary arterial segments through the wall of a quartz cell, using 8-40 mJ/pulse. In blood, 351 nm were delivered via an optical fiber, using 14 mJ/pulse. When the experiments were performed using an air-tissue interface, the dominant photoproducts identified in order of elution from the gas chromatographic column were methane, acetylene, ethylene, ethane, propyne, allene, propylene, propane, and butene. When a fiberoptic was used to accomplish 351-nm excimer laser tissue ablation in a blood field, a similar gas chromatographic spectral distribution was observed. These vapor-phase photoproducts are indistinguishable from those observed following continuous wave laser irradiation or flame torching of cardiovascular tissues. Thus, despite the fact that excimer laser ablation of cardiovascular tissues is characterized by the absence of signs of thermal injury, the results of these experiments suggest that the predominant mechanism of excimer ablation is, like continuous-wave laser irradiation, a thermal process.
