Age-induced increase of leucine enkephalin enzyme degradation in human plasma
Age-induced increase of leucine enkephalin enzyme degradation in human plasma
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DOI：
10.1016/s0196-9781(98)00061-8
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发表时间：
1998-01-01
期刊：
影响因子：
3
通讯作者：
Urbani, A
中科院分区：
文献类型：
--
作者：
Babst, R;Bongiorno, L;Urbani, A
在一组老年人中，用动力学和层析技术研究了在血浆酶存在的情况下，亮氨酸脑啡肽的水解率可能由年龄引起的变化。结果表明，老年人脑啡肽降解血浆酶的活性高于对照组；对这些数据的方差分析表明，两个年龄组的脑啡肽降解酶的变化具有统计学意义。底物水解率的增加和改进的水解式似乎与所涉及的酶的活性增加有关，与每类酶的不同分布有关，以及与低分子质量血浆抑制剂的活性严重降低有关。这些因素的组合为老年人定义了一种不同于对照组的特有的水解型。(C)1998年爱思唯尔科学公司。
Possible age-induced variations of the hydrolysis of leucine enkephalin in the presence of plasma enzymes were studied by kinetic and chromatographic techniques in a group of elderly individuals. Results obtained indicate that in elderly individuals the activity of enkephalin-degrading plasma enzymes is greater than in the controls; ANOVA analysis of these data indicates that the dependency of the variation of hydrolysis upon the two age groups is statistically significant. Increased substrate hydrolysis, and a modified hydrolysis pattern, appear to be associated with increased activity of the enzymes involved, and with different distribution of the individual enzymes within each class, as well as with severely reduced activity of the low molecular weight plasma inhibitors. The combination of these factors defines a characteristic hydrolysis pattern for the elderly individuals, different from that found in the controls. (C) 1998 Elsevier Science Inc.