Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver.
Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver.
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DOI：
10.2214/ajr.17.17812
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发表时间：
2017-09
期刊：
影响因子：
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通讯作者：
Reeder SB
中科院分区：
文献类型：
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作者：
Campo CA;Hernando D;Schubert T;Bookwalter CA;Pay AJV;Reeder SB
本研究的目的是评估ROI采样策略测量基于化学位移编码（CSE） mri的肝脏质子密度脂肪分数（PDFF）和R2* (1 / T2*)的可重复性（访谈者一致）和可重复性（访谈者一致）。第二个目的是标准化基于roi的肝脏PDFF和R2*测量，为图像分析人员提供测量再现性和可重复性与时间负担之间的折衷。回顾性分析两个队列的CSE数据。队列A包括53名转诊进行腹部MRI的患者和招募进行CT和MRI比较研究的健康受试者。B组包括37例疑似肝铁超载的患者。三位评论者使用先前报道的ROI采样策略测量肝脏PDFF和R2*。采用Bland-Altman分析评价访谈者间和访谈者肝脏PDFF的一致性和R2*。平均9个Couinaud节段的最大拟合roi导致两个队列中肝脏PDFF和R2*测量的最小一致限（LOA）。PDFF, interreviewer协议意味着贷款群组和±1.7%±0.8%的群体b Intrareviewer协议队列和±0.9%±0.5%为R2 * interreviewer队列b协议意味着贷款±3.0 s−1组A和17.9±s−1组b Intrareviewer协议±2.6 s−1组A和14.6±s−1组b .这种方法是最time-burdensome要求平均数±标准差为149.7±8.6 s /数据集。为了提高肝脏PDFF和R2*测量的再现性和可重复性，临床医生和研究人员应使用多个大roi对尽可能多的肝脏区域进行采样。
The purpose of this study was to evaluate the reproducibility (interreviewer agreement) and repeatability (intrareviewer agreement) of ROI sampling strategies to measure chemical shift–encoded (CSE) MRI-based liver proton density fat fraction (PDFF) and R2* (1 / T2*). A secondary purpose was to standardize ROI-based liver PDFF and R2* measurements by providing a compromise between measurement reproducibility and repeatability and time burden for image analysts. CSE data from two cohorts were retrospectively analyzed. Cohort A included 53 patients referred for abdominal MRI and healthy subjects recruited for a comparison study of CT and MRI. Cohort B included 37 patients with suspected liver iron overload. Three reviewers measured liver PDFF and R2* using previously reported ROI sampling strategies. Inter- and intrareviewer agreement of liver PDFF and R2* were evaluated using Bland-Altman analysis. Averaging largest-fit ROIs over the nine Couinaud segments resulted in the narrowest limits of agreement (LOA) for liver PDFF and R2* measurements in both cohorts. For PDFF, interreviewer agreement had mean LOA of ± 0.8% for cohort A and ± 1.7% for cohort B. Intrareviewer agreement was ± 0.5% for cohort A and ± 0.9% for cohort B. For R2* interreviewer agreement had mean LOA of ± 3.0 s−1 for cohort A and ± 17.9 s−1 for cohort B. Intrareviewer agreement was ± 2.6 s−1 for cohort A and ± 14.6 s−1 for cohort B. This approach was the most time-burdensome, requiring a mean ± SD of 149.7 ± 8.6 s per dataset. For improved reproducibility and repeatability of liver PDFF and R2* measurements, clinicians and researchers should sample as much area of the liver as possible using multiple large ROIs.