Diastereomeric fluoroolefins as peptide bond mimics prepared by asymmetric reductive amination of α-fluoroenones
Diastereomeric fluoroolefins as peptide bond mimics prepared by asymmetric reductive amination of α-fluoroenones
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DOI：
10.1002/anie.200604246
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Pannecoucke, Xavier
中科院分区：
文献类型：
--
作者：
Dutheuil, Guillaume;Couve-Bonnaire, Samuel;Pannecoucke, Xavier
模拟荧光肽：已经开发出一种有效的荧酮不对称还原胺化反应，它提供了潜在的氟肽等位体前体。不同还原剂的立体选择性路线提供了来自同一非外消旋亚磺酰亚胺的两个非对映异构体。将该方法应用于不同二肽类似物的合成。
Fluoropeptidomimetics: An efficient asymmetric reductive amination of fluoroenones has been developed that affords potential precursors of fluoropeptide isosteres. Stereoselective routes with different reductive agents provided both diastereomers from the same nonracemic sulfinyl imine. The method was applied to the synthesis of different dipeptide analogues.