A microfluidic lab-on-chip derivatisation technique for the measurement of gas phase formaldehyde
A microfluidic lab-on-chip derivatisation technique for the measurement of gas phase formaldehyde
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用于测量气相甲醛的微流控芯片实验室衍生技术
DOI：
10.1039/c2ay25028d
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发表时间：
2012-06
影响因子：
3.1
通讯作者：
Alastair C. Lewis
中科院分区：
文献类型：
--
作者：
Xiaobing Pang;Alastair C. Lewis
微流控芯片衍生化技术与GC-MS联用，实现了对环境气体甲醛的快速、自动化和灵敏测定。该方法使用Pyrex微反应器，包括3个入口和1个出口、气体和流体分流和合并通道、混合接头和2.0 m长、620 μm内径的反应微通道。该微反应器集混合反应、加热、预浓缩三大功能于一体。优化气体样品和衍生溶液的流速以及微反应器的温度，以在气体采样后通过快速高效的衍生步骤实现近实时测量。微反应器中相接触面积与体积比的提高和高传热速率导致了快速高效的衍生化反应。PFPH和PFBHA衍生物在26 ~ 331 ppb范围内线性关系良好，相关系数R2分别为0.988和0.997。对于低气相甲醛混合比（<26 ppb），衍生化溶液可以重复地再循环通过芯片，使得能够预浓缩衍生物-腙。该回收方法的校准曲线也显示出良好的线性范围为4.0至26 ppb，方法检测限（MDLs）为2.1 ppb和1.1 ppb的PFPH和PFBHA衍生物。该技术的可行性进行了评估，使用测量实验室环境空气中，甲醛的主要羰基化合物在12.5 ppb的水平。原理实验证明了该方法在线测量其他羰基化合物（包括乙醛、丙酮和丙醛）的潜力。
A microfluidic lab-on-chip derivatisation technique has been optimized to achieve a rapid, automated and sensitive determination of ambient gaseous formaldehyde when used in combination with GC-MS. The method used a Pyrex micro-reactor comprising three inlets and one outlet, gas and fluid splitting and combining channels, mixing junctions, and a 2.0 m long, 620 μm internal diameter reaction micro-channel. The micro-reactor integrated three functions, that of: (1) mixer and reactor, (2) heater, and (3) preconcentrator. The flow rates of the gas sample and derivatisation solution and the temperature of the micro-reactor were optimized to achieve a near real-time measurement with a rapid and high efficiency derivatisation step following gas sampling. The enhanced phase contact area-to-volume ratio and the high heat transfer rate in the micro-reactor resulted in a fast and high efficiency derivatisation reaction. Calibration showed good linearity in the range of 26 to 331 ppb with correlation coefficients R2 = 0.988 and 0.997 for PFPH and PFBHA derivatives. For low gas phase formaldehyde mixing ratios (<26 ppb) the derivatisation solution could be repeatedly recycled through the chip enabling pre-concentration of the derivative – hydrazone. The calibration curves for this recycling approach also showed good linearity from 4.0 to 26 ppb with method detection limits (MDLs) of 2.1 ppb and 1.1 ppb for PFPH and PFBHA derivatives. The feasibility of the technique was assessed using measurements of laboratory ambient air, with formaldehyde the predominant carbonyl compound at a 12.5 ppb level. The proof of principle experiments demonstrated the potential of the approach for on-line measurements of other carbonyls including acetaldehyde, acetone and propionaldehyde.
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影响因子：
11.4
作者：
Xianliang Zhou;Gu Huang;K. Civerolo;J. Schwab
通讯作者：
Xianliang Zhou;Gu Huang;K. Civerolo;J. Schwab
影响因子：
--
作者：
H. Singh;L. Salas;R. Chatfield;E. Czech;A. Fried;J. Walega;M. J. Evans;B. S. Field;D. Jacob;D. Blake;B. Heikes;R. Talbot;G. Sachse;J. Crawford;M. Avery;S. Sandholm;H. Fuelberg
通讯作者：
H. Singh;L. Salas;R. Chatfield;E. Czech;A. Fried;J. Walega;M. J. Evans;B. S. Field;D. Jacob;D. Blake;B. Heikes;R. Talbot;G. Sachse;J. Crawford;M. Avery;S. Sandholm;H. Fuelberg
影响因子：
5.2
作者：
F. Wittrock;A. Richter;H. Oetjen;J. Burrows;M. Kanakidou;S. Myriokefalitakis;R. Volkamer;S. Beirle-S.-Beir
通讯作者：
F. Wittrock;A. Richter;H. Oetjen;J. Burrows;M. Kanakidou;S. Myriokefalitakis;R. Volkamer;S. Beirle-S.-Beir
影响因子：
11.4
作者：
Mauro Aiello;R. McLaren
通讯作者：
Mauro Aiello;R. McLaren
北京环境空气中羰基化合物的季节和日变化
影响因子：
5
作者：
Pang, Xiaobing;Mu, Yujing
通讯作者：
Mu, Yujing