A review on current osteoporosis research: with special focus on disuse bone loss.
A review on current osteoporosis research: with special focus on disuse bone loss.
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DOI：
10.4061/2011/293808
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发表时间：
2011
影响因子：
1.9
通讯作者：
Guo X
中科院分区：
文献类型：
--
作者：
Lau RY;Guo X
骨质疏松症是一种多因素的骨骼疾病，其特征是骨量减少和微结构恶化，导致骨折风险增加。废用性骨质疏松症是指在机械载荷减少的情况下，航天员在太空飞行后的骨量减少，包括地力反应减少，肌肉收缩，以及与微重力相关的骨丢失。虽然对于原发性骨质疏松症有很多有效的治疗方法，但对于废用性骨质疏松症缺乏有效的治疗方法。这是因为废用性骨质疏松症的病因学、病理生理学和由此产生的病理学不同于原发性骨质疏松症。本文的目的是研究废用性骨质疏松症的独特病理和潜在的病理生理学。
Osteoporosis is a multifactorial skeletal disorder characterized by decreased bone mass and deteriorated microarchitecture that lead to increased risk of fracture. The disuse osteoporosis refers to bone mass decrements under conditions of decreased mechanical loading, including decreased ground force reaction, muscular contraction, and microgravity-related bone loss in astronauts after space flights. Although there are many effective treatments available for primary osteoporosis, there is a lack of effective treatments for disuse osteoporosis. This is because that the aetiology, pathophysiology, and resultant pathology of disuse osteoporosis differ from those of primary osteoporosis. The objective of this paper is to examine the unique pathology and underlying pathophysiology of disuse osteoporosis.