INDUCIBLE REPAIR OF OXIDATIVE DNA DAMAGE IN ESCHERICHIA-COLI
INDUCIBLE REPAIR OF OXIDATIVE DNA DAMAGE IN ESCHERICHIA-COLI
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DOI：
10.1038/304466a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
HALBROOK, J
中科院分区：
文献类型：
--
作者：
DEMPLE, B;HALBROOK, J
过氧化氢对许多细胞类型都是致命的，包括大肠杆菌1，2。过氧化物产生短暂的自由基物质，可以损害DNA 3并导致突变4。这种部分还原的氧物种偶尔会在细胞呼吸过程中释放2，并由致命和致突变的电离辐射产生5。由于细胞生活在一个持续存在DNA氧化损伤威胁的环境中，细胞机制可能已经进化到避免和修复这种损伤。酶是已知的，显然执行这些功能2，3。我们在这里报告，耐过氧化氢毒性可以诱导在E。这种新的诱导是特异性的，部分发生在DNA修复水平。
Hydrogen peroxide is lethal to many cell types, including the bacteriumEscherichia coli1,2. Peroxides yield transient radical species that can damage DNA3and cause mutations4. Such partially reduced oxygen species are occasionally released during cellular respiration2and are generated by lethal and mutagenic ionizing radiation5. Because cells live in an environment where the threat of oxidative DNA damage is continual, cellular mechanisms may have evolved to avoid and repair this damage. Enzymes are known which evidently perform these functions2,3. We report here that resistance to hydrogen peroxide toxicity can be induced inE. coli, that this novel induction is specific and occurs, in part, at the level of DNA repair.