Total synthesis of (+)-cylindramide A
Total synthesis of (+)-cylindramide A
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DOI：
10.1021/ja057899a
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发表时间：
2006-02-01
影响因子：
15
通讯作者：
Phillips, AJ
中科院分区：
文献类型：
--
作者：
Hart, AC;Phillips, AJ
用19步反应完成了圆柱胺A的合成。合成的关键步骤是串联的开环−闭环−交叉复分解反应，它将容易获得的降冰片烯转化为高级中间体。
A total synthesis of cylindramide A has been completed in 19 steps. The key step of the synthesis is a tandem ring-opening−ring-closing−cross metathesis that converts a readily available norbornene into an advanced intermediate.