Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy.
Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy.
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DOI：
10.1517/17425247.2012.676038
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发表时间：
2012-05
影响因子：
6.6
通讯作者：
Donnelly RF
中科院分区：
文献类型：
--
作者：
Al-Zahrani S;Zaric M;McCrudden C;Scott C;Kissenpfennig A;Donnelly RF
我们描述了使用微针阵列递送到皮肤本身内的靶点。突破皮肤的角质层屏障提高了疫苗、基因载体、抗体甚至纳米颗粒的施用的可能性，所有这些至少对皮肤细胞群体具有初始作用。特别是皮内注射疫苗具有改善患者治疗结果的巨大潜力，特别是发展中国家的患者。已经采用了各种疫苗输送策略，在这里我们依次讨论每一种策略。我们还描述了皮肤免疫生物学对微针介导的皮内接种所产生的效果的重要性。针介导的疫苗具有巨大的患者受益潜力。然而，为了使微针疫苗策略发挥其潜力，必须确定由于递送的疫苗对皮肤抗原呈递细胞的局部作用而引起的免疫应答的比例以及由于疫苗到达体循环而引起的全身效应的比例。此外，工业界需要大量投资于新设备和仪器，以便持续大规模生产微针疫苗。最后，微针需要在患者群体中表现出一致的剂量递送，并在它们取代久经考验的基于针头和注射器的方法之前将其与可靠的免疫反应相匹配。
We describe the use of microneedle arrays for delivery to targets within the skin itself. Breaching the skin’s stratum corneum barrier raises the possibility of administration of vaccines, gene vectors, antibodies and even nanoparticles, all of which have at least their initial effect on populations of skin cells. Intradermal vaccine delivery, in particular, holds enormous potential for improved therapeutic outcomes for patients, particularly those in the developing world. Various vaccine-delivery strategies have been employed and here we discuss each one in turn. We also describe the importance of cutaneous immunobiology on the effect produced by microneedle-mediated intradermal vaccination. Microneedle-mediated vaccine holds enormous potential for patient benefit. In order for microneedle vaccine strategies to fulfil their potential, however, the proportion of an immune response that is due to local action of delivered vaccines on skin antigen presenting cells and what is due to a systemic effect from vaccine reaching the systemic circulation must be determined. Moreover, industry will need to invest significantly in new equipment and instrumentation in order to mass produce microneedle vaccines consistently. Finally, microneedles will need to demonstrate consistent dose delivery across patient groups and match this to reliable immune responses before they will replace tried- and-tested needle-and-syringe based-approaches.
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DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
3.7
作者：
Fernando GJ;Chen X;Prow TW;Crichton ML;Fairmaid EJ;Roberts MS;Frazer IH;Brown LE;Kendall MA
通讯作者：
Kendall MA
影响因子：
3.7
作者：
Corbett HJ;Fernando GJ;Chen X;Frazer IH;Kendall MA
通讯作者：
Kendall MA
影响因子：
3.9
作者：
Bhowmik, Tuhin;D'Souza, Bernadette;D'Souza, Martin J.
通讯作者：
D'Souza, Martin J.
影响因子：
6.6
作者：
Frost, Gregory I.
通讯作者：
Frost, Gregory I.