X‐linked vacuolated myopathy: Membrane attack complex deposition on muscle fiber membranes with calcium accumulation on sarcolemma
X‐linked vacuolated myopathy: Membrane attack complex deposition on muscle fiber membranes with calcium accumulation on sarcolemma
复制标题
X连锁空泡性肌病：肌纤维膜上膜攻击复合物沉积，肌膜上钙积聚
作者：
J. Louboutin;M. Villanova;Brigitte Lucas‐Hérson;M. Fardeau
X连锁血管化肌病患者肌纤维上钙的细胞化学定位显示，在组织学异常的肌纤维中有强烈的肌膜或空泡钙沉积。所有的膜攻击复合物阳性纤维表现出这样的钙积累。与对照肌肉相比，X连锁空泡化肌病患者肌肉中的总钙含量显著升高。总而言之，这些结果表明，肌膜上的钙积聚可能是细胞表面膜攻击复合物沉积的次要原因。
Cytochemical localization of calcium on muscle fibers from patients with X‐linked vocuolated myopathy demonstrated strong sarcolemmal or vacuolar calcium deposits in histologically abnormal muscle fibers. All membrane attack complex—positive fibers demonstrated such calcium accumulation. Total content of calcium was significantly elevated in muscles from patients with X‐linked vacuolated myopathy compared to control muscles. Taken together, these results suggest that calcium accumulation on sarcolemma could be probably secondary to membrane attack complex deposition on the cell surface.
末端补体复合物产生的多个信号信使及其在末端补体复合物消除中的作用。
DOI：
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发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Carney,DF;Lang,TJ;Shin,ML
通讯作者：
Shin,ML