Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats.
Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats.
复制标题
立体定向给予大鼠 1-甲基-4-苯基吡啶鎓离子 (MPP ) 后的多巴胺能毒性。
DOI：
10.1016/0304-3940(85)90227-7
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发表时间：
1985
影响因子：
2.5
通讯作者：
Duvoisin,RC
中科院分区：
文献类型：
--
作者：
Heikkila,RE;Nicklas,WJ;Duvoisin,RC
将1-甲基-4-苯基吡啶鎓离子（MPP+）立体定向给予雌性大鼠的左侧新纹状体或左侧正中前脑束，导致左侧新纹状体中多巴胺及其代谢物大量且高度显著的损失。MPP+对新纹状体多巴胺含量的影响一般比其对5-羟色胺或几种氨基酸的影响大得多。这些结果与以下前提一致，即通过单胺氧化酶B由1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）形成的MPP+可能是MPTP给药后观察到的毒性的原因。
The administration of the 1-methyl-4-phenylpyridinium ion (MPP+) stereotaxically into the left neostriatum or left median forebrain bundle of female rats resulted in a very large and highly significant loss of dopamine and of its metabolites in the left neostriatum. The effect of MPP+on neostriatal dopamine content was in general considerably greater than its effect on serotonin or on several amino acids. These results are consistent with the premise that MPP+, formed from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by the enzyme monoamine oxidase B, may be responsible for the toxicity observed after MPTP administration.