Effects of bilateral vestibular lesions on orthostatic tolerance in awake cats
Effects of bilateral vestibular lesions on orthostatic tolerance in awake cats
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DOI：
10.1152/jappl.1999.86.5.1552
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发表时间：
1999-05-01
影响因子：
3.3
通讯作者：
Yates, BJ
中科院分区：
文献类型：
--
作者：
Jian, BJ;Cotter, LA;Yates, BJ
先前对麻醉或失智的猫进行的实验表明，前庭系统在体位变化过程中参与调节血压。本实验验证了一个假设，即去除清醒猫的前庭输入会影响直立耐受。在病变前，在鼻子向上倾斜的身体旋转幅度高达60度时，血压通常保持在基线值的10 mmHg以内。相比之下，双侧前庭周围病变改变了所有动物的直立反应模式，6只动物中有5只在鼻子向上倾斜60度时血压比基线值波动了10毫米汞柱。当动物也被剥夺了指示空间位置的视觉线索时，校正血压的缺陷尤其大。在此测试条件下，80%的受试者血压下降或升高幅度为10mmhg。前庭病变后血压调节障碍仅持续1周，此后倾斜期间血压保持稳定。这些数据表明，去除前庭信号会改变直立反应，这与前庭信号是运动过程中引起代偿性血压变化的几个输入信号之一的假设是一致的。
Previous experiments in anesthetized or decerebrate cats showed that the vestibular system participates in adjusting blood pressure during postural changes. The present experiments tested the hypothesis that removal of vestibular inputs in awake cats would affect orthostatic tolerance. Before the lesion, blood pressure typically remained within 10 mmHg of baseline values during nose-up-pitch body rotations of up to 60 degrees in amplitude. In contrast, bilateral peripheral vestibular lesions altered the pattern of orthostatic responses in all animals, and blood pressure fluctuated >10 mmHg from baseline values during most 60 degrees nose-up tilts in five of six animals. The deficit in correcting blood pressure was particularly large when the animal also was deprived of visual cues indicating position in space. During this testing condition, either a decrease or increase in blood pressure >10 mmHg in magnitude occurred in >80% of tilts. The deficit in adjusting blood pressure after vestibular lesions persisted for only 1 wk, after which time blood pressure remained stable during tilt. These data show that removal of vestibular inputs alters orthostatic responses and are consistent with the hypothesis that vestibular signals are one of several inputs that are integrated to elicit compensatory changes in blood pressure during movement.