Comparison of paroxetine and amitriptyline in the treatment of refractory globus pharyngeus
Comparison of paroxetine and amitriptyline in the treatment of refractory globus pharyngeus
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DOI：
10.1016/j.dld.2016.05.025
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发表时间：
2016-09-01
影响因子：
4.5
通讯作者：
Xu, Jian
中科院分区：
文献类型：
--
作者：
Chen, Dong-yun;Jia, Lin;Xu, Jian
背景：抗抑郁药治疗癔球症的临床试验通常很少，更不用说治疗难治性咽球症了。目的：探讨抗抑郁药物帕罗西汀与阿米替林治疗难治性癔球症患者的疗效及副作用。方法：将难治性癔球症患者随机分为帕罗西汀组；阿米替林组和兰索拉唑组治疗6周。所有受试者均被要求在治疗前和治疗后完成以下问卷：格拉斯哥爱丁堡咽喉量表 (GETS)、匹兹堡睡眠质量指数、汉密尔顿焦虑/抑郁评定量表和医疗结果简表 36。治疗反应定义为 GETS 评分降低 > 50%。 结果：148 名患者完成了研究。治疗6周后，帕罗西汀组有效率71.7%（33/46），显着高于阿米替林组（46.2%，24/52）和兰索拉唑组（14.0%，7/50）。与兰索拉唑组或阿米替林组相比，治疗6周后，帕罗西汀组在情绪健康、生活质量和睡眠质量方面有更明显的改善。结论：帕罗西汀治疗比经验性大剂量抗分泌治疗甚至小剂量阿米替林治疗更能有效缓解难治性癔球症患者的球状症状，并使整体改善。 (C) 2016 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: Clinical trials of antidepressants for treatment of globus are generally rare, let alone for refractory globus pharyngeus. Aims: To illustrate the efficacy and side-effects of antidepressants between paroxetine and amitriptyline for refractory globus patients.Methods: Refractory globus patients were randomized into paroxetine group; amitriptyline group and lansoprazole group for 6-week treatment. All the subjects were asked to complete the following questionnaires pre- and post-therapy: Glasgow Edinburgh Throat Scale (GETS), Pittsburgh Sleep Quality Index, Hamilton Rating Scale Anxiety/Depression and Medical outcome short-form 36. Treatment response was defined as a >50% reduction in the GETS score.Results: One hundred and forty-eight patients completed the study. After 6 week treatment, 71.7% of paroxetine group (33/46) were calculated as treatment response, significantly higher than that in amitriptyline group (46.2%, 24/52) and lansoprazole group (14.0%, 7/50). Compared with lansoprazole group or amitriptyline group, a more distinct improvement of emotional well-being, quality of life and quality of sleep were observed in paroxetine group after 6-week treatment.Conclusion: Paroxetine therapy is more efficacious than empirical high-dose antisecretory treatment, or even the low-dose amitriptyline therapy in alleviating globus symptoms, and producing global improvements for refractory globus patients. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.