Identification of substandard and falsified antimalarial pharmaceuticals chloroquine, doxycycline, and primaquine using surface-enhanced Raman scattering
Identification of substandard and falsified antimalarial pharmaceuticals chloroquine, doxycycline, and primaquine using surface-enhanced Raman scattering
复制标题
使用表面增强拉曼散射识别不合格和伪造的抗疟药物氯喹、多西环素和伯氨喹
DOI：
10.1039/c8ay01413b
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Camden, Jon P.
中科院分区：
文献类型：
--
作者：
Tackman, Emma C.;Trujillo, Michael J.;Lockwood, Tracy-Lynn E.;Merga, Getahun;Lieberman, Marya;Camden, Jon P.
伪造的抗疟药物是一个世界性问题，对公共健康产生负面影响。在这里，我们开发了一种表面增强拉曼散射（SERS）协议来识别市售片剂中存在的不合格和伪造的抗疟药物。在记录纯氯喹、伯氨喹和多西环素的 SERS 光谱后，SERS 用于测量在常见药用囊片赋形剂存在下配制为活性药物成分 (API) 的这些药物。为了证明我们方法的可行性，还进行了一项红队研究，其中发现了所有三种未知药物的低质量和伪造配方。这些数据与便携式拉曼光谱仪的有希望的结果相结合表明 SERS 是一种用于药物质量现场分析的可行技术。
Falsified antimalarial pharmaceuticals are a worldwide problem with negative public health implications. Here, we develop a surface-enhanced Raman scattering (SERS) protocol to recognize substandard and falsified antimalarial drugs present in commercially available tablets. After recording SERS spectra for pure chloroquine, primaquine, and doxycycline, SERS is used to measure these drugs formulated as active pharmaceutical ingredients (APIs) in the presence of common pharmaceutical caplet excipients. To demonstrate the viability of our approach, a red team study was also performed where low-quality and falsified formulations of all three drugs presented as unknowns were identified. These data in conjunction with promising results from a portable Raman spectrometer suggest that SERS is a viable technique for on-site analysis of drug quality.