PROGNOSIS AND LIFE EXPECTANCY IN CHRONIC LIVER-DISEASE
PROGNOSIS AND LIFE EXPECTANCY IN CHRONIC LIVER-DISEASE
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DOI：
10.1007/bf02212706
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发表时间：
1995-08-01
影响因子：
3.1
通讯作者：
VOGEL, W
中科院分区：
文献类型：
--
作者：
PROPST, A;PROPST, T;VOGEL, W
本研究的目的是确定不同病因的慢性肝病患者的预后和预期寿命，并将它们与年龄和性别匹配的正常人群联系起来。经过15年的随访，对620名慢性肝病患者的预期寿命进行了回顾性计算，并与年龄和性别匹配的正常人进行了比较。人口。在肝硬变患者中，预后取决于Child分级(P=0.001)。酒精性肝硬变和脂肪性肝病患者年龄较小(P=0.004)，预期寿命较低(P=0.05)。与年龄和性别匹配的人群相比，乙肝和丙型肝炎肝硬变患者的预后相似，预期寿命显著降低。隐源性和自身免疫性肝病的预期寿命与正常人群相似，但预期寿命明显短于正常人群。在α(1)-抗胰蛋白酶缺乏症合并肝硬变患者中，病毒重叠感染率较高(P=0.01)。对于非肝硬化性血色沉着症患者，预后比年龄和性别匹配的人群更差。在无症状的原发性胆汁性肝硬变、慢性迁延性乙肝和无肝硬变的α(1)-抗胰蛋白酶缺乏症患者中，预期寿命与正常人群相同。慢性肝病的预后和预期寿命取决于慢性肝病的分期、病因和症状、年龄和治疗的可能性。在遗传性肝病患者中，额外的病毒感染或酗酒会导致预期寿命显著恶化。酒精性慢性肝病患者预后最差。
The aim of the present study was to define prognosis and life expectancy in patients with chronic liver disease of different etiologies and to relate them to an age- and sex-matched normal population. After a follow-up of 15 years, life expectancy of 620 patients with chronic liver disease was retrospectively calculated and compared with an age- and sex-matched normal. population. Among patients with cirrhosis, prognosis was dependent upon the Child classification (P = 0.001). Patients with alcoholic cirrhosis and fatty liver disease were younger (P = 0.01) and had a lower life expectancy than patients with other causes of chronic liver disease (P = 0.004). Patients with hepatitis B and hepatitis C cirrhosis showed a comparable prognosis and a significantly lower life expectancy than the age- and sex-matched population. Cryptogenic and autoimmune liver diseases showed a comparable life expectancy but a significantly shorter life expectancy than the normal population. In patients with alpha(1)-antitrypsin deficiency-associated cirrhosis, a high viral coinfection rate was found (P = 0.01). For patients with noncirrhotic hemochromatosis, prognosis was poorer than that for the age- and sex-matched population. In patients with asymptomatic primary biliary cirrhosis, chronic persistent hepatitis B, and alpha(1)-antitrypsin deficiency without cirrhosis, life expectancy was equal to that of the normal population. Prognosis and life expectancy in chronic liver disease depend on stage, cause, and symptoms of chronic liver disease; age; and possibilities of treatment. In patients with hereditary liver disease, additional viral infection or alcohol abuse lead to a significant deterioration of life expectancy. Patients with alcoholic chronic liver disease have the poorest prognosis.