Biocompatibility of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) modified by silk fibroin
Biocompatibility of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) modified by silk fibroin
复制标题
丝素蛋白修饰聚(3-羟基丁酸酯-co-3-羟基己酸酯)的生物相容性
DOI：
10.1007/s10856-006-9686-8
复制
发表时间：
2006-08-01
影响因子：
3.7
通讯作者：
Chen, Guo-Qiang
中科院分区：
文献类型：
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作者：
Mei, Na;Zhou, Ping;Chen, Guo-Qiang
当受损组织不再自然再生时，用作组织支架的材料在引导组织创建新的功能结构方面发挥着重要作用[1]。材料是否适合作为组织支架取决于其物理和化学性能，如机械性能、降解性以及重要的生物相容性。组织工程中使用的大多数生物材料是聚乳酸（PLA）和聚乙醇酸（PGA）[2-4]。但其亲水性差[5，6]和相对较高的结晶度[7，8]在一定程度上限制了其应用。例如，以前的PGA制造的组织工程心脏瓣膜的实验仅成功地作用于低压肺循环[9]。最近，聚羟基链烷酸酯（PHA），一种由细菌合成的作为细胞内碳和能量储存化合物的热塑性生物聚酯类[10-12]，被广泛应用于生物可降解塑料。此外，由于其弹性和易于成型的特性，它被认为是组织工程心脏瓣膜和软骨的候选者[13][14]。PHAs家族是最常见的生物材料
The materials used as tissue scaffolds play an important role for guiding the tissue to create a new functional structure when the damaged tissue is no longer regenerated naturally [1]. Whether or not the material is suitable for tissue scaffold depends on its physical and chemical properties, such as mechanical properties, degradability and, importantly, biocompatibility. Most of biomaterials used in tissue engineering are poly (lactic acid)(PLA) and poly (glycolic acid)(PGA)[2–4]. But their poor hydrophilicity [5, 6] and relatively high crystallinity [7, 8] restrict their application in some degree. For example, previous experiments of tissue engineered heart valves fabricated by PGA only successfully acted at the low-pressure pulmonary circulation [9]. Recently, polyhydroxyalkanoate (PHA), a thermoplastic elastomor class of biopolyesters synthesized by the bacteria as an intracellular carbon and energy storage compound [10–12], is widely applied as biodegradable plastics. Moreover, it is recognized as a candidate for tissue engineered heart valve and cartilage [13] because of its elastic and easily moldable properties [14]. Of PHAs family, the most common member as biomaterial