Effects of prenatal exposure to atypical antipsychotics on postnatal development and growth of infants: a case-controlled, prospective study
Effects of prenatal exposure to atypical antipsychotics on postnatal development and growth of infants: a case-controlled, prospective study
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DOI：
10.1007/s00213-013-3060-6
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发表时间：
2013-08-01
影响因子：
3.4
通讯作者：
Zhao, Jingping
中科院分区：
文献类型：
--
作者：
Peng, Mei;Gao, Keming;Zhao, Jingping
本研究旨在调查非典型抗精神病药物对在整个怀孕期间服用非典型抗精神病药物的母亲所生婴儿的发育影响。将 76 名胎儿接触过非典型抗精神病药物的婴儿的发育进展与 76 名胎儿未接触过任何抗精神病药物的对照婴儿的发育进展进行了比较。计划评估包括阿普加评分、体重、身高以及贝利婴幼儿发展量表第三版 (BSID-III) 的认知、语言、运动、社会情感和适应性行为综合评分。酌情使用学生 t 检验和卡方分析。通过协方差分析对重复测量进行评估。 2 个月大时，非典型抗精神病药物暴露婴儿的 BSID-III 认知、运动、社会情感和适应行为的平均综合评分显着低于对照组。更多非典型抗精神病药物暴露婴儿在认知、运动、社会情感和适应性行为领域出现发育迟缓，如 BSID-III 这些分量表的综合得分 < 85 所定义的。 12 月龄时，两组 BSID-III 的所有平均综合评分均无显着差异。尽管两组之间的平均出生体重和身高没有显着差异，但接触非典型抗精神病药物的婴儿出生体重较对照组低（13.2% vs. 2.6%，P = 0.031）。 胎儿接触非典型抗精神病药物可能会导致认知、运动、社会情感和适应性行为的短期发育迟缓，但不会导致语言、体重或身高发育迟缓。
This study aims to investigate the developmental effects of atypical antipsychotics on infants who were born to mothers taking an atypical antipsychotic throughout pregnancy.The developmental progress of 76 infants who experienced fetal exposure to atypical antipsychotics was compared to that of 76 matched control infants who had no fetal exposure to any antipsychotics. Planned assessment included Apgar score, body weight, height, and the cognitive, language, motor, social-emotional, and adaptive behavior composite scores of the Bayley Scales of Infant and Toddler Development, third edition (BSID-III). Student's t test and Chi-square analysis were used as appropriate. Repeated measurements were evaluated by analysis of covariance.At 2 months of age, the mean composite scores of cognitive, motor, social-emotional, and adaptive behavior of BSID-III were significantly lower in atypical antipsychotic-exposed infants than the controls. More atypical antipsychotic-exposed infants had delayed development in cognitive, motor, social-emotional, and adaptive behavior domains as defined by the composite score of < 85 in these subscales of BSID-III. At 12 months of age, there were no significant differences between the two groups in all mean composite scores of BSID-III. More atypical antipsychotic-exposed infants had low birth weight than the controls (13.2 vs. 2.6 %, P = 0.031), although there were no significant difference in mean birth weight and height between the two groups.Fetal exposure to atypical antipsychotics may cause short-term delayed development in cognitive, motor, social-emotional, and adaptive behavior, but not in language, body weight, or height.