Disorders of vertical optokinetic nystagmus in patients with ocular misalignment
Disorders of vertical optokinetic nystagmus in patients with ocular misalignment
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DOI：
10.1016/s0042-6989(02)00387-5
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发表时间：
2003-02-01
期刊：
影响因子：
1.8
通讯作者：
Leigh, RJ
中科院分区：
文献类型：
--
作者：
Garbutt, S;Han, YN;Leigh, RJ
目的。比较患有眼排列障碍的患者对垂直和水平视动 (OK) 刺激的反应。方法。使用磁搜索线圈技术，我们测量了六名自童年以来患有斜视的患者和八名正常受试者的双眼水平和垂直旋转。 OK刺激水平72度，垂直60度，由空间频率为0.04周期/度的黑白条纹组成，并以22.5或12度/秒的速度垂直或水平移动。所有患者和对照均通过双眼观察和单眼观察进行测试。结果。大多数正常人和患者的垂直 OK 反应是不对称的。这种不对称的方向因人而异，但向上的刺激比向下的刺激更常见地引起更大的反应。正常人单眼水平 OK 反应是对称的；患者要么表现出不对称性，对鼻运动反应较大，要么表现出方向性偏差。在单眼和双眼观看过程中，垂直OK刺激会引起正常受试者的垂直眼球震颤，但所有患者均表现出对角线反应，其水平分量显着大于对照组。反应的不适当的水平分量在较高的刺激速度下增加，并且不仅仅是由于潜在的眼球震颤。结论。自童年起就有眼位失调的患者对垂直 OK 刺激表现出不适当的水平反应，表明运动视觉通路或眼部运动反应的方向异常。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Purpose. To compare responses to vertical and horizontal optokinetic (OK) stimulation in patients with disorders of ocular alignment.Methods. Using the magnetic search coil technique, we measured horizontal and vertical rotations of both eyes in six patients with strabismus since childhood and eight normal subjects. The OK stimulus subtended 72degrees horizontally and 60degrees vertically, consisted of black-and-white stripes with a spatial frequency of 0.04 cycles/degree, and moved either vertically or horizontally at 22.5 or 12degrees/s. All patients and controls were tested with both eyes viewing and monocularly.Results. Vertical OK responses were asymmetric in most normals and patients. The direction of this asymmetry varied between individuals, but upward stimuli more commonly elicited a greater response than downward stimuli. Monocular horizontal OK responses were symmetric in normals; patients showed either an asymmetry with greater responses for nasal motion, or a directional bias. During monocular and binocular viewing, vertical OK stimulation induced vertical nystagmus in normal subjects, but all patients showed diagonal responses, with horizontal components that were significantly greater than controls. The inappropriate horizontal component of the response increased at the higher stimulus speed, and was not simply due to latent nystagmus.Conclusions. Patients with disorders of ocular alignment since childhood show an inappropriate horizontal response to vertical OK stimuli, indicating directional abnormality of either motion vision pathways or the ocular motor response. (C) 2002 Elsevier Science Ltd. All rights reserved.